解偶联蛋白2与衰老  

Uncoupling protein 2(UCP_2) and Aging

作　　者：胡祥上[1] 邹原[2] 

机构地区：[1]湖南怀化医学高等专科学校基础医学部,湖南怀化418000 [2]大连医科大学生理学教研室,辽宁大连116044

出　　处：《现代生物医学进展》2009年第2期388-390,共3页Progress in Modern Biomedicine

摘　　要：解偶联蛋白(uncoupling protein,UCP)属于线粒体内膜上的一类载体蛋白,其生理作用是消除线粒体膜电位,使氧化磷酸化解偶联,从而抑制酸腺苷(adenosine triphosphate,ATP)合成,能量以热能形式散发。研究发现UCP2具有一种质子漏功能,表现对线粒体活性氧(reactive oxygen species,ROS)产生的调控和降低ROS的功能。在不同组织器官,不同代谢状态下UCP2的生理功能对细胞的影响不完全相同。特别是近年来的研究发现,UCP2参与了能量代谢、ROS的产生、子宫内膜退化、衰老等过程,并且与非酒精性脂肪肝、抗肥胖、动脉粥样硬化、局部缺血以及缺血再灌注损伤和2型糖尿病等有一定的相关性,倍受人们的关注。UCP belongs to a kind of bearer protein in mitochondrial. Its physiologic function is to eliminate the potential ofmito- chondria by uncoupling oxidative phosphorylation, thereby it restrains the synthesis of ATP and the energy gives off in the form of heat. The researches show that UCP2 has a function of proton leakage, appearing with its regulation and control towards the ROS in the respiratory chain in mitochondrial inner membrane and the debasing of the function of ROS. But in different organs and organizations and in different metabolic state, the influence of the physiologic function of UCP2 upon cells are not totally the same. Especially, recent re- searches show that UCP2 participates in the process of energy metabolism, the creation of ROS, the deqeneration ofendometrium and caducity and so on. It also has relation with nonspirituous hepatic adipose infiltration, obesity, atherosclerosis, ischemia, reperfusion injury and the type 2 diabetes mellitus, so it has aroused world attention.

关 键 词：解偶联蛋白 质子漏 活性氧 衰老 

分 类 号：Q419[生物学—生理学]