COX-2在胶质母细胞瘤中的表达及与肿瘤增殖和凋亡的关系  

The expression and significance of COX-2 in glioblastomas

作　　者：王代旭[1] 黄元奎[1] 牛洪泉[2] 张华平[1] 潘险峰[3] 

机构地区：[1]华中科技大学同济医学院附属荆州医院神经外科,湖北荆州434020 [2]华中科技大学同济医学院附属同济医院神经外科,湖北武汉430030 [3]华中科技大学同济医学院附属荆州医院肿瘤科,湖北荆州434020

出　　处：《现代肿瘤医学》2009年第2期221-223,共3页Journal of Modern Oncology

基　　金：荆州市科技局资助项目(编号:20071PE1-8)

摘　　要：目的:探讨环氧化酶-2(COX-2)在胶质母细胞瘤中的表达,及其与肿瘤凋亡和增殖的关系。方法:采用免疫组化S-P法检测34例星形细胞瘤患者和10例正常脑组织COX-2和Bcl-2、Ki-67的表达,用TUNEL法检测肿瘤细胞凋亡,并计算其凋亡指数(AI)。结果:胶质母细胞瘤组织中COX-2的阳性表达率明显高于对照组;Bcl-2和Ki-67在肿瘤组织中的表达均高于对照组,且和COX-2表达呈正相关性。结论:胶质母细胞瘤中COX-2的过表达可抑制肿瘤细胞的凋亡,促进细胞增殖,其抑制凋亡的作用可能是通过提高Bcl-2的阳性表达实现的,在胶质母细胞瘤的发生和发展中起重要作用。Objective： To investigate the expression of cyclooxygenase - 2 （ COX - 2 ） in glioblastomas, and analyze the correlation with apoptosis, proliftertion of the tumors. Methods： The expression of COX -2 and Ki -67, Bcl - 2 was detected by immunohistochmical （ S - P） method in 34 glioblastomas and 10 cases normal brain tissue. Apoptosis cells were detected by TUNEL. Results： The positive expression rates of COX - 2, Bcl - 2 and Ki - 67 in glioblastomas were significantly higher than those in the control group. There was positive correlation between expression of COX - 2 and that of Bcl - 2 and Ki - 6. Conclusion ： Overexpression of COX - 2 in the glioblastomas can inhibit cell apoptosis, and induce glioblastomas proliferate, so play an important role in glioblastomas development and progression.

关 键 词：胶质母细胞瘤 环氧化酶-2 KI-67 BCL-2 凋亡 

分 类 号：R730.264[医药卫生—肿瘤]