STAT3和survivin在人胶质瘤中的表达及意义  

Expression and its significance of STAT3 and survivin in human neurogliomas

作　　者：周任[1] 张龙洲[1] 王睿智[1] 包新杰[1] 

机构地区：[1]西安交通大学第二附属医院神经外科,陕西西安710004

出　　处：《现代肿瘤医学》2009年第2期227-229,共3页Journal of Modern Oncology

摘　　要：目的:研究STAT3和survivin在人胶质瘤中的表达及其与肿瘤恶性程度之间的关系。方法:用免疫组化法检测并比较60例不同级别胶质瘤和10例正常脑组织中STAT3和survivin的表达情况,并对二者表达做相关性分析。结果:STAT3和survivin在正常脑组织中无表达,在瘤组织中的表达均随肿瘤病理级别的升高而增高,相关性分析显示二者的表达存在正相关。结论:STAT3在胶质瘤的发生发展中起重要作用,其作用可能与诱导survivin的高表达有关。Objective： To study the expression of STAT3 and survivin in different malignant human gliomas. Methods： Immunohistochemical SP method was employed to examine the expression of STAT3 and survivin in 60 cases of glioma, 10 cases of normal cerebral tissue as control group. Meanwhile the relationship of STAT3 and survivin expression was analyzed. Results： Both the expression of STAT3 and survivin increased as the malignant grade increased, at the same time the expression of STAT3 was positively related to that of survivin. Conclusion： The STAT3 may play a vital role in the development of glioma through induction of survivin.

关 键 词：胶质瘤 STAT3 SURVIVIN 

分 类 号：R730.264[医药卫生—肿瘤]