Livin、Smac在上皮性卵巢癌中的表达及意义  

The expression and significance of Livin and Smac in epithelial ovarian carcinoma tissues

作　　者：焦伊胜[1] 王永来[1] 张淑兰[1] 刘晓梅 郝凤进[3] 

机构地区：[1]中国医科大学附属盛京医院妇产科,辽宁沈阳110004 [2]中国医科大学附属盛京医院中心实验室,辽宁沈阳110004 [3]中国医科大学生物化学教研室,辽宁沈阳110001

出　　处：《现代肿瘤医学》2009年第2期296-299,共4页Journal of Modern Oncology

基　　金：辽宁省教育厅高等学校科研项目(编号:05L475)

摘　　要：目的:探讨凋亡抑制蛋白Livin和凋亡促进因子Smac与上皮性卵巢癌临床病理学特征的关系。方法:利用免疫组化技术SABC法检测50例上皮性卵巢癌、20例良性卵巢瘤和20例正常卵巢组织中Livin和Smac的表达情况。结果:Livin在卵巢恶性肿瘤中的表达明显高于正常卵巢组织和卵巢良性肿瘤组织。在上皮性卵巢癌组织中,Livin的表达与组织病理学分级成正相关,与分期无关;Smac在卵巢癌中的表达低于良性卵巢瘤及正常卵巢组织,与组织病理学分级、分期成负相关,表达出现逐渐降低的趋势。结论:Livin表达升高和Smac表达降低在上皮性卵巢癌的发生、分化进展过程中起重要作用。Livin和Smac基因有可能成为治疗卵巢癌的新靶标。Objective：To study the expression of Livin and Smac in epithelial ovarian carcinoma tissues and their relationship with clinical characteristic. Methods ： Immunohistochemieal SABC method and image analysis system were used to observe the expression of Livin and Smac proteins in 20 normal ovarian tissues ,20 benign ovarian tumor tissues and 50 malignant epithelial ovarian carcinoma tissues. Results：The expression level of Livin in malignant tumor was significantly higher than those in normal ovarian tissues and benign tumor tissues（ P 〈 0.01 ）. There was a positive correlation between the expression of Livin and the tumor grade and was no statistically significant correlation between tumor stage;The expression of Smac in malignant tumor was lower than those in normal tissues and benign tumor tissues （P 〈 0.01 ）and was negatively related to tumor stage and tumor grade（ P 〈 0.05 ）. Conclusion：The increased expression of Livin and depressed expression of Smac may play an important role in the process of carcinogenesis and differentiation of epithelial ovarian carcinoma; Livin and Smac may be useful targets for treatment of ovarian carcinoma.

关 键 词：LIVIN SMAC 卵巢肿瘤 免疫组化 

分 类 号：R737.31[医药卫生—肿瘤]