全反式维甲酸(ATRA)联合柔红霉素与阿糖胞苷对高细胞急性早幼粒细胞白血病(APL)的疗效  

Effect of all-trans-retinoic-acid combind with DA on high cell crisis of acute promyelocytic leukemia

作　　者：闫晓婷[1] 史素芳[1] 

机构地区：[1]河北省复员军人医院内二科,河北邢台054000

出　　处：《现代肿瘤医学》2009年第2期328-329,共2页Journal of Modern Oncology

摘　　要：目的:观察全反式维甲酸(ATRA)联合柔红霉素(DNR)与阿糖胞苷(Ara-C)双诱导方案对高细胞急性早幼粒细胞白血病(APL)的疗效。方法:ATRA40-60mg/d,分2-3次口服;DNR 40mg加入250ml生理盐水中,缓慢静滴,d1-3;Ara-C100mg加入250ml 5%葡萄糖液中,静脉点滴,d1-7;继续口服ATRA至完全缓解(CR)。结果:24例患者均在30-45天内达CR,除3例出现发热感染外,24例未见严重出血、DIC,仅1例出现轻度维甲酸综合征,予地塞米松6mg后消失。结论:ATRA联合DA双诱导化疗方案治疗APL,较单用ATRA达CR时间明显缩短,无1例发生高白细胞综合征及严重维甲酸综合征,表明双诱导方案既具有诱导白血病细胞分化又有抑制其增殖作用,疗效可靠安全。Objective： To explore the effect of all - trans - retinoic - acid （ATRA） combined with daunorubicin （DNR） and cytosine arabinoside （ Ara - C ） on high cell crisis of acute promyelocytie leukemia （APL）. Methods： ATRA was given 40 - 60mg per day （ Bid or rid ） , and DNR 40mg, administerd intravenously in 250ml normal saline from l -3 days and Ara - C100mg administerd intravenously in 250ml 5 % glucose solution for 1 -7 days, then continue to take ATRA orally untill complete remission. Results：Twenty four cases were complete remission without severe hemorrhage symprom and DIC ,3 cases had fever with infection, and 1 case had ATRA syndrome. Conclusion：Time of CR treating APL with ATRA combined double ADEP is shorter than that of ATRA, double ADEP is safe and reliable.

关 键 词：全反式维甲酸 化学治疗 白血病 早幼粒细胞 

分 类 号：R733.7[医药卫生—肿瘤]