川芎的氢核磁共振-模式识别法研究  

Identification of Rhizoma chuanxiong based on 1HNMR- PRA

作　　者：黄连[1] 黄静[1,2] 江洪波[1] 胡小兵[1] 刘涛 

机构地区：[1]四川大学华西药学院,四川成都610041 [2]四川大学口腔疾病研究国家重点实验室,四川成都610041 [3]四川抗生素研究所,四川成都610052

出　　处：《华西药学杂志》2009年第1期68-70,共3页West China Journal of Pharmaceutical Sciences

基　　金：口腔疾病研究国家重点实验室自主研究基金资助(SKLOD-P1-001)

摘　　要：目的建立鉴别川芎真伪的方法。方法以1HNMR法测定川芎乙醚提取物,将图谱转化为数据矩阵,分别采用PCA、PLS-DA两种模式识别方法分析数据。结果1HNMR-PCA或1HNMR-PLS-DA两种方法均能有效地区分川芎正品、伪品及次品;后者还能进一步区分川芎与近似品日本川芎。结论基于全成分的1HNMR-PRA是一种有效的鉴别川芎正品、次品、伪品的新方法,对其他中药药材的鉴别亦具有参考价值。OBJECTIVE To establish a new identification method of Ligusticum chuanxiong based on 1 HNMR - PRA. METHODS 1 HNMR spectra of ether - extracts of samples were examined, and 1HNMR spectra were translated to a digital matrix, then PCA and PLS - DA were used to analyze the digital matrix. RESULTS 1HNMR - PCA and 1 HNMR - PLS - DA methods could distinguish the Rhizoma chuanxiong. CONCLUSION ~ HNMR - PCA based on all components analysis was a new useful method to identify Rhizoma chuanxiong. It was also a good reference method for other tranditional Chinese medicines.

关 键 词：川芎 模式识别 核磁共振氢谱 主成分分析法 偏最小二乘法 

分 类 号：R917[医药卫生—药物分析学]