美满霉素增强血管性痴呆大鼠自由基清除  

Minocycline enhances clearance of free radicals in vascular dementia rats

作　　者：蔡志友[1] 晏勇[1] 余昌胤[2] 张骏[2] 黄良国[2] 晏宁[1] 承欧梅[1] 吴芳[1] 李洁颖[1] 赵宇[1] 

机构地区：[1]重庆医科大学附属第一医院神经内科重庆市神经病学重点实验室,重庆400016 [2]遵义医学院附属医院神经内科

出　　处：《中国老年学杂志》2009年第3期294-296,共3页Chinese Journal of Gerontology

基　　金：重庆医科大学博士课题基金(2006010068)

摘　　要：目的观察美满霉素(minocycline)对血管性痴呆(VD)大鼠脑组织和血清SOD、MDA、GSH-Px、LPO表达的影响,探讨其对血管性痴呆脑保护作用机制。方法Wistar大鼠随机分组:正常组、假手术组、痴呆模型组、美满霉素治疗组。采用生物化学法检测大鼠脑组织和血清SOD、MDA、GSH-Px、LPO表达水平。结果美满霉素组MDA、GSH-Px、LPO表达较模型组降低(P<0.05),美满霉素组SOD表达较模型组增高(P<0.05);美满霉素组SOD、MDA、GSH-Px、LPO表达较正常组和假手术组增高(P<0.01);模型组SOD、MDA、GSH-Px、LPO表达较正常组和假手术组显著增高(P<0.01)。结论美满霉素能降低VD大鼠脑组织和血清MDA、GSH-Px、LPO水平、增强SOD表达,通过清除VD大鼠自由基、抑制氧化应激效应发挥其脑保护作用。Objective To investigate the influence of Minocycline on expressions of SOD, MDA, GSH-Px, LPO in brain and serum of vascular dementia （VD） rats,to study the neuroprotection mechanism of Minocycline on VD. Methods Wistar rats were randomly divid- ed into normal, sham, VD model and minocycline groups. The levels of SOD, MDA, GSH-Px, LPO in brain and serum were measured by biochemistry. Results The levels of MDA, GSH-Px, LPO in minocycline group were lower and the level of SOD was higher than those of VD model group （P 〈 0. 05 ）, the levels of SOD, MDA, GSH-Px, LPO in minocyeline group and VD model group were higher than those of nor- mal and sham groups （P 〈0. 01 ）. Conclusions Minocycline can reduce the expressions of MDA, GSH-Px, LPO and increase the expression of SOD in brain and serum of VD rats. Through clearing the free radicals and restraining oxidative stress, Minocycline has the effect of neuroprotection.

关 键 词：血管性痴呆 美满霉素 自由基 

分 类 号：R749.16[医药卫生—神经病学与精神病学]