卵巢恶性生殖细胞肿瘤预后因素分析  

Analysis of Prognostic Factors in Patients with Malignant Ovarian Germ Cell Tumor

作　　者：侯志敏[1,2] 薛凤霞[1] 

机构地区：[1]天津医科大学总医院,天津300052 [2]天津市人民医院妇产科,天津300120

出　　处：《实用妇产科杂志》2009年第1期19-22,共4页Journal of Practical Obstetrics and Gynecology

摘　　要：目的:分析影响卵巢恶性生殖细胞肿瘤(MOGCT)预后的相关因素。方法:回顾性分析天津医科大学总医院和天津市人民医院1987年1月至2004年12月的65例MOGCT的临床和随访资料,探讨影响MOGCT预后的相关因素。结果:MOGCT总的2年和5年生存率分别为53.64%和51.85%,差异无统计学意义(P>0.05)。MOGCT的预后因素包括:肿瘤病理类型、FI-GO分期、腹水量和术后残存瘤灶直径。无性细胞瘤和未成熟畸胎瘤是预后较好的病理类型(P<0.05),早期预后好于进展期(P<0.01),腹水量<100 ml(P<0.05)和残存瘤灶直径≤2 cm(P<0.01)具有较好预后。结论:应重视MOGCT初次治疗时的临床分期、病理类型和腹水量,施行彻底的减瘤术和规范的辅助化学治疗可改善预后,提高患者的生存率和生活质量。Objective： To explore the prognostic factors of patients with malignant ovarian germ call tumor （ MOGCT）. Methods： The prognostic factors of MOGCT was retrospective studied in 65 cases who came to General Hospital of Tianjin Medical University and Tianjin Union Medical Center from January, 1987 to December, 2004. Results： The 2-year and 5-year survival rates of MOGCT were 53.64% and 51.85% respectively（ P 〉 0.05）. Prognostic factors of MOGCT involved：staging, pathological type, ascites volume and residual tumor size. Prognosis of patients with dysgerminoma and immature teratoma was better than that in patients with other pathological types （ P 〈 0.05）, patients with stage I had a more favorable prognosis than those with stage III and IV disease （ P 〈 0.01 ） ,cases in which ascites was either absent or 〈 100 ml （ P〈 0.05）and cases in which the size of residual tumor was ≤2cm（ P 〈 0.01） had a more favorable prognosis. Conclusions： Staging, pathological type and ascites volume of MOGCT should be considered at the initial treatment, thorough tumor-reductive surgery and assistant chemotherapy can strongly affected the prognosis, improve the survival rate and quality of life.

关 键 词：卵巢恶性生殖细胞肿瘤 生存率 预后因素 

分 类 号：R737.31[医药卫生—肿瘤]