Breast cancer-specific serum peptide profiles  

作　　者：WANG Na WEN XinYu WANG Jie LI AiLing LI WeiHua LI Tao Li Yan ZHANG XueMin WANG HongXia YANG SongCheng ZHOU Tao GONG WeiLi TIAN YaPing HE Kun 

机构地区：[1]National Center of Biomedical Analysis, Beijing 100850 [2]Chinese People's Liberation Army General Hospital, Beijing 100853

出　　处：《Chinese Science Bulletin》2009年第3期421-429,共9页

基　　金：Supported by National Natural Science Foundation of China (Grant No. 30321003);National Key Basic Research and Development Program of China (Grant No. 2004CB518800)

摘　　要：Early detection of breast cancer is paramount to successful clinical therapy. Yet, early-stage breast cancer lacks specific symptoms or biomarkers. With the emerging of the mass spectrometric (MS) -based signatures as biomarkers, we investigated breast cancer-related serum profile pattern through class prediction and independent validation, and used Fourier transfer MS to identify breast cancer signature. We now show a distinctive serum peptide pattern that discriminates breast cancer from healthy controls with 93.2% sensitivity and 95.4% specificity. m/z 5901.70 and 4465.74 of ion fragment of FPA and alpha1-antichymotrypsin are found in the signatures that predominantly discriminate breast cancer from healthy individuals. These novel findings identify an MS-based serum peptide pattern of breast cancer that may have direct clinical utility in future.Early detection of breast cancer is paramount to successful clinical therapy. Yet, early-stage breast cancer lacks specific symptoms or biomarkers. With the emerging of the mass spectrometric （MS） -based signatures as biomarkers, we investigated breast cancer-related serum profile pattern through class prediction and independent validation, and used Fourier transfer MS to identify breast cancer signature. We now show a distinctive serum peptide pattern that discriminates breast cancer from healthy controls with 93.2% sensitivity and 95.4% specificity, m/z 5901.70 and 4465.74 of ion fragment of FPA and alphal-antichymotrypsin are found in the signatures that predominantly discriminate breast cancer from healthy individuals. These novel findings identify an MS-based serum pepUde pattern of breast cancer that may have direct clinical utility in future.

关 键 词：乳腺癌 光谱测定法 血浆肽 生物标记 

分 类 号：R737.9[医药卫生—肿瘤]