SAPAP3基因多态性与强迫症的关联性分析  

Association between SAPAP3 gene polymorphism and obsessive compulsive disorder

作　　者：谢冰[1] 寇长贵[1] 史杰萍[1] 赵旭善[1] 赵凌云[1] 杨莉[1] 刘建智[1] 刘洋[1] 于雅琴[1] 黄悦勤[2] 

机构地区：[1]吉林大学公共卫生学院流行病学与卫生统计学教研室吉林大学医学基因组研究中心,吉林长春130021 [2]北京大学精神卫生研究所,北京100083

出　　处：《吉林大学学报（医学版）》2009年第1期150-153,共4页Journal of Jilin University：Medicine Edition

基　　金：吉林省科技厅科技发展计划项目资助课题(200505135);吉林大学“大学生创新性试验计划”项目资助课题(2007B72094)

摘　　要：目的:探讨SAPAP3基因多态性与强迫症的关系,为强迫症的易感基因研究奠定基础。方法:采用聚合酶链式反应-限制性内切酶片段长度多态性(PCR-RFLP)方法对190例强迫症大学生和190例健康大学生SAPAP3基因上的标签SNP位点rs11264155进行基因型检测。结果:rs11264155位点PCR扩增目的片段长度为219 bp,经酶切后呈现CC、CG、GG 3种基因型;rs11264155位点基因型频数分布符合Hardy-Weinberg平衡定律;rs11264155位点在病例组和对照组中基因型频数和等位基因频数分布差异无显著性(P>0.05);该位点的基因型频数和等位基因频数在不同临床类型的强迫症大学生中分布差异无显著性(P>0.05)。结论:SAPAP3基因tag SNP rs11264155位点的多态性可能与强迫症的发生无关联。Objective To investigate the association between SAPAP3 gene polymorphism and obsessive compulsive disorder and provide theoretical basis for its susceptibility gene study. Methods The method of PCR-RFLP was conducted to examine the genotypes of a tag SNP rs11264155 locus on SAPAP3 gene in 190 obsessive compulsive disorder undergraduates （case group） and 190 healthy undergraduates （control group）. Results The fragment of rs11264155 was 219 bp, and three genolypes （CC, CG, GG） were found after digestion. The distribution of genotypic frequency of rs11264155 was consistent with Hardy Weinberg equilibrium. The frequencies of allele and genotype of rs11264155 showed no significant difference between case and control groups （PD0. 05）. In different clinical types of obsessive compulsive disorder, the frequencies of allele and genotype of rs11264155 showed no significant difference （P〉0.05）. Conclusion The tag SNP rs11264155 of SAPAP3 gene may not be associated with obsessive compulsive disorder.

关 键 词：强迫症 SAPAP3 标签SNP 

分 类 号：R749[医药卫生—神经病学与精神病学]