糖皮质激素与脂肪代谢和胰岛素抵抗  

Glucocorticoids,Adipose Metabolism and Insulin Resistance

作　　者：徐冲[1] 徐国恒[1] 

机构地区：[1]北京大学医学部生理学与病理生理学系,北京100191

出　　处：《生理科学进展》2009年第1期19-23,共5页Progress in Physiological Sciences

基　　金：国家自然科学基金(30770803;30670779);北京市自然科学基金(5072030);国家重大基础研究计划项目(2009CB941603)资助课题

摘　　要：内源性和外源性糖皮质激素过多会导致胰岛素抵抗和发展为糖尿病。糖皮质激素增加循环中葡萄糖、胰岛素和游离脂肪酸(FFA)浓度。循环中FFA增高与肥胖、胰岛素抵抗和2型糖尿病密切相关,其主要来源于脂肪细胞内甘油三酯水解。糖皮质激素刺激脂肪分解、增加FFA构成了激素导致胰岛素抵抗的重要机制之一。Obesity, insulin resistance, and type 2 diabetes are associated with elevated concentration of circulating free fatty acid （FFA） , which is critically governed by the process of triglyceride lipolysis in adipocytes. Endogenous and exogenous glucocorticoids excess could induce insulin resistance and diabetes. Thus, the effects of glucocorticoids stimulating adipose lipolysis and elevating FFA release may contribute to glucocorticoids-induced insulin resistance and diabetes. This review focuses on the regulation and function of glucocorticoids in adipose lipolysis and metabolism.

关 键 词：糖皮质激素 脂肪分解 胰岛素抵抗 游离脂肪酸 

分 类 号：Q591.5[生物学—生物化学]