β-环糊精的双官能化  

Bifunctionalization of β-Cyclodextrin

作　　者：李迎照[1] 尹传奇[1] 李世荣[2] 柏正武[1,3] 

机构地区：[1]武汉工程大学化工与制药学院,湖北武汉430073 [2]湖北民族学院生物资源保护与利用湖北省重点实验室,湖北恩施445000 [3]武汉工程大学绿色化工过程省部共建实验室,湖北武汉430073

出　　处：《合成化学》2009年第1期109-111,共3页Chinese Journal of Synthetic Chemistry

基　　金：国家自然科学基金资助项目(20675061)

摘　　要：通过两条路线对β-环糊精进行双官能化合成了3个带双官能团的β-环糊精——叠氮基对甲苯磺酰基β-环糊精（3），二对甲苯磺酰基β-环糊精（4）和二叠氮基β-环糊精（5）。对甲苯磺酰基β-环糊精（1）的对甲苯磺酰基被叠氮基取代制得单叠氮基β-环糊精（2）；2与对甲苯磺酰咪唑反应得到3。1先与对甲苯磺酰咪唑反应生成4；4的对甲苯磺酰基被叠氮基取代得到5。3—5的结构经^1H NMR，IR和元素分析表征。Three fl-cyclodextrin derivatives with bifunctional group were synthesized by two ways to achieve bifunctionalization of β-cyclodextrin. Azido-tosyl-β-cyclodextrin was prepared from tosyl-β-cyclodextrin （1） by the substitution with azide, then by the reaction with tosylated imidazole. 1 reacted first with tosylated imidazole to obtain ditosyl-β-cyclodextrin （4）, then ditosyls of 4 were substituted by azides to give diazido-β-eyelodextrin. The structures were characterized by ^1 H NMR, IR and elemental analysis.

关 键 词：Β-环糊精 对甲苯磺酰基化 双官能团 合成 

分 类 号：O629.12[理学—有机化学]