急性Guillain-Barré综合征患者外周血单核细胞TNFα及IL-6的变化  

Changes of tumor necrosis factor α and interleukin 6 released from blood monocytes in acute Guillain Barré syndrome

作　　者：卢宏[1] 方树友[1] 宋志宇[1] 

机构地区：[1]河南医科大学第一附属医院神经内科

出　　处：《中华神经科杂志》1998年第2期76-78,共3页Chinese Journal of Neurology

基　　金：河南省科委重点攻关项目

摘　　要：目的探讨肿瘤坏死因子α（ＴＮＦα）及白细胞介素６（ＩＬ６）在急性ＧｕｉｌａｉｎＢａｒé综合征（急性ＧＢＳ）免疫病理机制中的作用。方法采用体外细胞培养方法和免疫微量检测技术对急性ＧＢＳ患者外周血单核细胞经大肠杆菌内毒素（ＬＰＳ）诱导后产生ＴＮＦα、ＩＬ６的能力进行研究。结果急性ＧＢＳ患者外周血单核细胞ＴＮＦα、ＩＬ６水平明显增高，与其他神经疾病组和正常对照组比较有显著差异，且与病情有关。结论急性ＧＢＳ患者血单核细胞处于活化状态，自身免疫功能异常，ＴＮＦα、ＩＬ６可能参与了急性ＧＢＳ的免疫病理过程，且与病情的轻重有密切关系。Objective To study cytokines action in Guillain Barré (GBS) immunopathogenesis. Method The capacity of blood monocytes stimulated by Lipopolysaccharide to generate tumor necrosis factor α(TNFα) and interleukin (IL 6) in GBS patients were measured with radioimmunoasay and enzyme linked immunosorbent assay. Results The levels of TNFα and IL 6 in the culture media of the GBS patients were significantly elevated over those of the other neurological diseases and the normal controls. The elevated levels of TNFα and IL 6 in the patients with GBS correlated directly with the severity of the diseases. Conclusion All results suggested the following: the blood monocytes of the GBS patients might be in an activated state. The patients with GBS had some disorder in their immune system, the levels of TNFα and IL 6 might play an important role in the immunopathological process of GBS and might have an evident correlation with the severity of this disease.

关 键 词：单核细胞 肿瘤坏死因子 白细胞介素6 G-B综合征 

分 类 号：R745.43[医药卫生—神经病学与精神病学]