顶空气相色谱法测定盐酸头孢替安中残留溶剂——丙酮、二氯甲烷、乙酸甲酯  

作　　者：李朝庆[1] 林萍[1] 陈妍[1] 

机构地区：[1]哈药集团制药总厂,黑龙江哈尔滨150086

出　　处：《黑龙江科技信息》2009年第7期185-185,共1页Heilongjiang Science and Technology Information

摘　　要：目的:建立一种气相色谱法同时测定盐酸头孢替安中有机溶剂丙酮、二氯甲烷、乙酸甲酯残留量的方法。方法:采用内标法顶空自动进样,在非极性弹性毛细管柱上进行分离,效果良好。结论:方法重现性好,定量准确,便于操作。结果:平均回收率;丙酮98.0%;-103.8%;二氯甲烷96.7%-102.0%;乙酸甲酯108.0%-102.5%;变异系数;丙酮1.5%,二氯甲烷2.2%,乙酸甲酯1.9%。Aim： using the headspace Gas-chromatography methods to detect the content of residual solvent （acetone, Methylene dichloride and methyl acetate） in Cefotiam Hydrochloride in the same time. Method： auto-injection using internal standard headspace method, isolating with the nonpolarity flexibility capillary column, the result is good. Conclusion： using the method can obtain a good repeatability, make the quantity accurate and make it is easy to operate. Results： the average recovery percentage： acetone 98.0%-103.8%, Methylene dichloride 96.7%-102.0%, methyl acetate 108.0%-102.5%. Coefficient of variation： acetone 1.5%, Methylene dichloride 2.2%, methyl acetate 1.9%.

关 键 词：顶空气相色谱法 盐酸头孢替安 残留溶剂 丙酮 二氯甲烷 乙酸甲酯 

分 类 号：TQ222.214[化学工程—有机化工] X832.02[环境科学与工程—环境工程]