次声对雄性大鼠精子质量和睾丸组织抗氧化系统的影响  

Effects of infrasound on sperm quality and tissue antioxidant system in testes of rats

作　　者：李瑞满[1] 庄志强[2] 裴兆辉[2] 

机构地区：[1]暨南大学附属第一医院妇产科,广东广州510630 [2]中山大学附属第一医院心内科,广东广州510080

出　　处：《中国病理生理杂志》2009年第2期373-376,共4页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金资助项目(No.30400091)

摘　　要：目的:观察次声作用对大鼠精子质量的影响,初步探讨次声对雄性生殖系统的作用机制。方法:成年雄性SD大鼠分别经8Hz、90dB或130dB的次声作用l、7、14、2ld(2h/d),取副睾检测其精子计数、畸形率和活动率,取同侧睾丸检测谷胱甘肽过氧化物酶(GSH-Px)和丙二醛(MDA)水平。结果:8Hz、90dB和130dB次声作用组随次声作用时间延长,精子质量下降,MDA水平升高,GSH-Px下降。在同一时点上,130dB次声作用组的各项指标与90dB组相比,变化更为显著。结论:次声对睾丸的生物学效应与其作用参数有关,抗氧化系统失衡可能是该效应的发生机制。AIM： To observe the effects of infrasound on sperm quality and explore some underlying mechanisms. METHODS： Adult male SD rats were exposed to infrasound of 8 Hz at 90 dB or 130 dB for 1,7,14 or 21 d （2 h/d）, whose epididymises were obtained for sperm count, abnormity and activity ratio inspection and whose testes for GSH - Px and MDA inspection. RESULTS： With prolonged exposure, sperm quality and GSH -Px in 90 dB and 130 dB groups decreased, while MDA increased, and at the same time point, the indexes of 130 dB groups changed more profoundly than those in 90 dB groups. CONCLUSION： Biological effect of infrasound on testes depends on the exposure parameters. The mechanisms of which could be unbalanced antioxidant system induced by infrasonic exposure.

关 键 词：大鼠 睾丸 精子质量 谷胱甘肽过氧化酶 丙二醛 

分 类 号：R363[医药卫生—病理学]