Bestrophin氯通道的研究进展  

Growing insights into bestrophin

作　　者：王觅[1] 关永源[1] 

机构地区：[1]中山大学中山医学院药理学教研室,广东广州510080

出　　处：《中国药理学通报》2009年第2期151-153,共3页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No30730105)

摘　　要：Bestrophin是最新发现的一类Cl-通道,其同源序列广泛存在于动物、真菌、原核生物。Bestrophin受到Ca2+、细胞容积和自身结构的调节。在嗅觉传导、视网膜色素上皮细胞液体的转运以及细胞的增殖中发挥了重要作用。Bestrophins have recently been proposed to comprise a new family of chloride channels. Homologous sequences have been found in animals, fungi and prokaryotes. Bestrophins are regulated by Ca^2＋ , cell volume as well as auto-inhibitory domainand play important roles in olfactory transduction, fluid transport and cell proliferation.

关 键 词：BESTROPHIN CL^-通道 卵黄样黄斑变性 

分 类 号：R-05[医药卫生] R329