胃癌的表观遗传学研究  

Epigenetics on gastric cancer research

作　　者：贾岩[1] 郭明洲[1] 杨云生[1] 

机构地区：[1]中国人民解放军总医院消化科,北京100853

出　　处：《胃肠病学和肝病学杂志》2009年第2期92-96,共5页Chinese Journal of Gastroenterology and Hepatology

摘　　要：胃癌高度恶性且预后较差,目前随着对胃癌基础研究的不断深入,表观遗传学改变在胃癌发生发展中的重要作用逐渐被人们认识,因此可通过检测基因的异常甲基化等表观遗传学改变对胃癌进行早期诊断、治疗及预后评价。本文总结分析胃癌相关基因甲基化状态及表观遗传学的临床应用前景,以期探讨表观遗传学对胃癌的早期诊断及治疗的指导作用。Gastric cancer （GC） is a highly malignant neoplasm with poor prognosis. It was regarded as an important mechanism of epigenetie changes in gastric cancer. DNA methylation may be used as gastric cancer detection or prognosis markers. In this article, we summarized the characteristics of epigenetic changes about tumor-related genes and its clinical applications in gastric cancer. It is possible to apply epigeneties changes for gastric cancer early diagnosis and treatment.

关 键 词：胃癌 表观遗传学 CPG岛 DNA甲基化 组蛋白修饰 

分 类 号：R735.2[医药卫生—肿瘤]