NHE1 mRNA在肝癌组织的表达及意义  

Clinical significance and expression of NHE1 mRNA in hepatocellular carcinoma tissues

作　　者：李杰[1] 窦科峰[1] 张洪涛[1] 张超[1] 李韧[1] 张福琴[1] 王德盛[1] 

机构地区：[1]第四军医大学附属西京医院肝胆外科,陕西西安710032

出　　处：《胃肠病学和肝病学杂志》2009年第2期121-122,共2页Chinese Journal of Gastroenterology and Hepatology

基　　金：国家自然科学基金(304004425);陕西省科技研究发展计划项目(2008k09-05)

摘　　要：目的探讨钠氢交换蛋白1(NHE1)mRNA在原发性肝细胞肝癌组织及癌旁组织的表达及意义。方法采用RT-PCR检测诊断为HCC患者34例的肝癌及癌旁组织中NHE1 mRNA的表达情况。结果所有肝癌组织和癌旁组织NHE1均有表达,相对表达量分别为2.892±0.882和0.802±0.206,两者存在显著性差异(P<0.001)。作为对照的21例肝组织NHE1的相对表达量为0.872±0.186。肝癌组织与对照肝组织比较存在显著性差异(P<0.001);癌旁组织与对照肝组织比较差异无统计学意义(P>0.10)。将从同一患者取材的肝癌组织和癌旁组织检测到的NHE1 mRNA的表达量进行配对t检验,两者间存在显著性差异(P<0.001)。结论NHE1 mRNA在肝癌组织的表达增高,可能在肝癌的发生中起一定的作用。Objective To study the expression of Na＋/H ＋ exchanger 1 （NHE1） mRNA in primary hepatocellular carcinoma （HCC） tissues, and to discuss its value in the development of HCC. Methods RT-PCR was used to detect the expression of NHE1 mRNA in the tissues of 34 HCC and its paraneoplastie tissues and 21 non-HCC liver tissues from the other patients. Results NHE1 mRNA was expressed widely. The relative intensities of its expression in HCC, paraneoplastic tissues, non-HCC liver tissues were respectively 2. 892 ±0. 882, 0. 802±0. 206 and 0. 872 ±0. 186. Conclusion NHE1 mRNA may play an important role for the development of HCC.

关 键 词：肝细胞癌 钠氢交换蛋白1 

分 类 号：R735.7[医药卫生—肿瘤]