乳腺癌体外药敏实验结果分析及价值  

Value of Chemosensitivity Assay In Vitro on Breast Cancer

作　　者：黄正有 李致文[1] 覃运荣[1] 

机构地区：[1]广西玉林市红十字会医院普外一科,玉林537000

出　　处：《中国普外基础与临床杂志》2009年第2期145-147,共3页Chinese Journal of Bases and Clinics In General Surgery

摘　　要：目的探讨肿瘤体外药敏实验对乳腺癌个体化化疗的应用价值。方法采用组织块培养-终点染色-计算机图像分析(TECIA)法检测38例乳腺癌对6种常用化疗药物的体外肿瘤药物敏感性。结果38例乳腺癌组织对化疗药物的敏感性由高到低依次为:多柔比星、紫杉醇、长春瑞滨、环磷酰胺、顺铂及氟尿嘧啶。结论TECIA法的体外肿瘤药敏实验对指导乳腺癌的临床用药及个体化化疗具有重要价值。Objective To explore the value of chemosensitivity assay in vitro on breast cancer. Methods In vitro chemosensitivity of 6 species of chemotherapeutic agents applied to 38 cases of breast cancer patients were detected by tissue culture-end point staining-computer image analysis （TECIA）. Resu｜ls The sensitivity to chemotherapeutic agents commonly used in the breast cancer level from high to low was as follow： Doxorubicin （ADM）, Paclitaxel （TAX）, Vinorelbine （NVB）, Cyclophosphamide （CTX）, Cisplatin （DDP） and Fluorouracil （FU）. Conclusion Drugs sensitivity experiment of cancer in vitro by TECIA has an important value to instruct clinical medication and individual chemotherapy for breast cancer.

关 键 词：肿瘤药敏试验 乳腺癌 组织块培养-终点染色-计算机图像分析 个体化化疗 

分 类 号：R737.9[医药卫生—肿瘤]