癫痫清片对慢性致痫大鼠海马区氨基酸含量的影响  

Effects of Dianxianqing Slice on the Content of Amino Acid in Hippocampus of Rats with Chronic Epilepsia Induced by Lidocaine Injection

作　　者：贾冬[1] 齐越[1] 夏素霞[1] 乔敏[1] 朱艳菊[1] 张芳[1] 王丽红[1] 

机构地区：[1]辽宁中医药大学,辽宁沈阳110032

出　　处：《辽宁中医杂志》2009年第2期303-304,共2页Liaoning Journal of Traditional Chinese Medicine

基　　金：辽宁省自然科学基金资助项目(20052076)

摘　　要：目的:探讨癫痫清片(DXQ)对慢性致痫大鼠氨基酸含量的影响。方法:采用腹腔注射利多卡因(Lidocaine)造成慢性癫痫大鼠模型,以高效液相色谱法(HPLC)检测海马区氨基酸的含量。结果:癫痫清片可使癫痫大鼠海马区兴奋性氨基酸Glu、Asp的含量减少,抑制性氨基酸GABA含量升高,与模型组比较具有统计学意义(P<0.05)。结论:癫痫清片可调节海马区兴奋性和抑制性氨基酸含量的平衡失调,从而减轻癫痫大鼠发作程度和发作时间。Objective： To investigate the effects of Dianxianqing Slice（DXQS） on the content ofamino acid （AA） in hippocampus of rats with chronic epilepsia induced by lidocaine injection. Methods ： The animal model with chronic epilepsia was prepared by intraperitoneal injection of lidocaine. Then ,DXQS was given to these modeling animals and AA content in hippocampus was detexmined bythe end of experiment with HPLC. Results ： The animals in treating group showed the contents of excitatory AAs （EAAs） like Glu and Asp were significantly reduced and that of inhibitory AA like GABA was markedly elevated in hippocampus of these animals treated with DXQS,when compared with that of modeling animals. Conclusions： DXQS may bring abouttherapeutic effects on epilepsy via regulating the contents of EAAs and IAAs to keep them in a balanced satuation among these experimental amimals.

关 键 词：癫痫清片 癫痫 利多卡因 氨基酸 高效液相色谱荧光法 

分 类 号：R284.1[医药卫生—中药学]