GPX3启动子rs8177412基因多态性与脑梗死的相关性研究  

The Correlative study Between rs8177412 of promoter Polymorphisms in the Plasma Glutathione Peroxidase(GPX-3) gene and arterial ischemic stroke

作　　者：赵中[1] 黄开梅[1] 陈伟贤[2] 高炳忠[1] 周沁[1] 邱晨红[1] 杨义伟[3] 

机构地区：[1]南京医科大学附属苏州医院神经内科,江苏苏州215001 [2]南京医科大学第一附属医院神经内科,江苏南京210029 [3]金坛市人民医院检验科,江苏金坛213200

出　　处：《南京医科大学学报（自然科学版）》2009年第2期186-189,共4页Journal of Nanjing Medical University(Natural Sciences)

摘　　要：目的:探讨血浆谷胱甘肽过氧化酶(Plasma Glutathione Peroxidase,GPX-3)启动子rs8177412位点基因多态性与脑梗死的相关性。方法:采用聚合酶链反应-连接酶检测方法(PCR-LDR)对94例脑梗死患者和80例健康对照者进行GPX-3启动子基因多态性分析。结果:脑梗死患者组中rs8177412位点TC+CC基因型频率分别高于对照组(P<0.05),其C等位基因频率亦高于对照组(P<0.05)。经多项非条件logistic回归分析提示GPX-3启动子rs8177412携带C等位基因可能为脑梗死的独立危险因素。结论:GPX-3启动子rs8177412基因多态性与脑梗死的发生有关,可能是脑梗死的一个重要危险因素。Objectives：To investigate the correlation between the rs8177412 of promoter polymorphisms in the plasma Glutathione Peroxidase（GPX-3） gene and arterial isehemie Stroke. Methods：Ninety four patients（patient group） with arterial ischemic stroke and eighty heahy subjects （control group） were recruited in the study, and promoter polymorphisms of the plasma Glutathione Peroxidase （GPX-3） gene were detected using polymerase chain reaction and ligase detection reaetion（PCR-LDR）. Results：At rs8177412 site of the Plasma Glutathione Peroxidase（GPX-3） Promoter Gene, the frequency of TC＋CC-type and the frequency of C alleles respectively were increased in the patient group than that in the control group （P 〈 0.05）. Conclusions：There were some relationships between rs8177412 of promoter polymorphisms in the plasma glutathione peroxidase（GPX-3 gene and arterial ischemic Stroke, and they may be an important risk factor for stroke.

关 键 词：血浆谷胱甘肽过氧化酶 基因多态性 脑梗死 

分 类 号：R743.3[医药卫生—神经病学与精神病学]