老年性痴呆患者事件相关电位P300和多导睡眠图对照研究  

A comparision of ERP P300 and polysomnogram in patients with senile dementia

作　　者：宋景贵[1] 张朝辉[1] 穆俊林[1] 李冲[1] 顾仁骏[1] 

机构地区：[1]新乡医学院第二附属院

出　　处：《中国康复医学杂志》2009年第2期133-135,共3页Chinese Journal of Rehabilitation Medicine

基　　金：河南省医学科技创新人才工程项目(2005069)

摘　　要：目的:探讨老年性痴呆患者事件相关电位(ERP)和多导睡眠图(PSG)之间的关系。方法:对36例临床诊断的老年性痴呆患者及35例年龄匹配的健康人进行对照研究,所有受试者均进行ERP和PSG测试。结果:研究组中ERP测定的异常率为94.4%(34/36),ERP中N2、P3波潜伏期较对照组延长,P3波幅降低,其差异具有显著性意义(P<0.01),PSG测定睡眠潜伏期延长、觉醒次数和S1阶段增多、总睡眠时间、深睡眠(S3+S4)、快眼动睡眠时间和睡眠纺锤波指数减少、睡眠效率降低与对照组比较差异有显著性意义(P<0.01)。ERP成分中P3波潜伏期P3波幅与PSG测定中睡眠潜伏期、觉醒次数、总睡眠时间、深睡眠、快眼动睡眠时间、睡眠效率及纺锤波指数等指标存在显著的相关性(P<0.01)。结论:老年性痴呆患者存在明显的认知功能减退和睡眠质量下降。ERP和PSG可以作为老年性痴呆患者早期诊断的辅助指标。Objective： To explore the characteristic of event-related potential（ERP） P300 and polysomnogram（PSG） in patients with senile dementia （SD）. Method： A total of 36 SD patients and 35 age-matched person （control group） were studied. All the cases were assessed with ERP and PSG, and the results were compared between the two groups. Result： The abnormal rate of ERP in SD patients was 94.4% （34/36）.In SD patients group latency of N2 and P3 of ERP were longer and the amplitude of P3 were lower than those in the controls. There were significant difference between two groups（P〈0.01）. Compared with normal controls, in SD patients the sleep latency prolonged; awareness frequency and stage Ⅰsleep increased; total sleep time, slow-wave sleep （stage Ⅲ- Ⅳ）, rapid eye movement （REM）, index of sleep spindle and sleep efficacy decreased remarkably （P〈0.01）. Correlation analysis showed that there was a remarkable correlation in latency and amplitude of P3 of ERP with sleep latency, awareness frequency ,total sleep time,slow-wave sleep,rapid eye movement,sleep efficacy and sleep spindle of PSG in SD patients （P〈0.01）. Conclusion： The patients with senile dementia had remembrance cognition degeneration and sleep disorder. It suggested that ERP and PSG test could be served as indexes for early diagnosis of senile dementia.

关 键 词：老年性痴呆 认知 睡眠 事件相关电位 多导睡眠图 

分 类 号：R749.1[医药卫生—神经病学与精神病学] R493[医药卫生—临床医学]