重症急性胰腺炎中肠道免疫功能紊乱的研究进展  

Advancement of intestinal function disorders in severe acute pancreatitis

作　　者：罗旭颖[1] 王红[1] 

机构地区：[1]首都医科大学附属北京友谊医院感染暨急救医学科,北京市100050

出　　处：《世界华人消化杂志》2009年第2期169-173,共5页World Chinese Journal of Digestology

摘　　要：重症急性胰腺炎患者常伴有肠黏膜透性增高,肠黏膜免疫功能异常,出现肠道菌群、内毒素移位,引起继发感染,诱发多脏器功能不全,死亡率极高.因此,肠黏膜通透性增高及免疫功能异常与重症急性胰腺炎病程后期继发感染密切相关.但肠黏膜免疫功能异常的确切机制尚不明确,有待于进一步研究.Recent studies indicate that increased intestinal permeability and changes of intestinal mucosal immune function are very common in patients with severe acute pancreatitis （SAP）. And they may be the main reasons for bacterial and endotoxin translocation, which are associated with secondary infection and multiorgan dysfunction syndrome in SAP. However, the accurate mechanism underlying the abnormality of intestinal mucosal immune dysfunction is not clarified, which deserves further study.

关 键 词：肠黏膜免疫功能 肠黏膜通透性 重症急性胰腺炎 

分 类 号：R576[医药卫生—消化系统]