心得安对食管曲张静脉套扎后再出血的影响  

Effects of propranolol on rebleeding following endoscopic esophageal variceal ligation: a prospective, controlled trial

作　　者：程文芳[1] 施瑞华[1] 陈晓星[1] 丁静[1] 

机构地区：[1]南京医科大学第一附属医院消化内科,江苏省南京市210029

出　　处：《世界华人消化杂志》2009年第1期83-85,共3页World Chinese Journal of Digestology

摘　　要：目的:观察心得安对食管曲张静脉套扎后再出血的影响.方法:78例门脉高压性食管静脉曲张(esophageal varices,EV)患者,分成单独套扎组(39例,作为对照组)和心得安组(39例,套扎后给予心得安,10mg,3次/d,po).比较两组套扎后12mo内再出血率,同时12mo后复查胃镜,比较两组患者门脉高压性胃病及胃底曲张静脉发生率.结果:套扎12mo后再出血率心得安组明显低于对照组(38.70%vs54.54%,P<0.05).心得安组门脉高压性胃病发生率、胃底静脉发生率,食管静脉再发率均明显低于对照组(32.25%vs57.57%,25.80%vs42.42%,29.03%vs39.39%,均P<0.05).结论:心得安可降低食管曲张静脉套扎后再出血,其原因是心得安能够降低套扎后的门脉高压性胃病和食管、胃底静脉曲张的发生.AIM： To observe the effects of propranolol on rebleeding following endoscopic esophageal variceal ligation. METHODS： Seventy-eight patients undergoing esophageal varices received either ligation alone （control group： n = 39） or a combination of ligation and propranolol （propranolol group： n = 39）. Twelve months after ligation, endoscopic evaluation of rebleeding, portal hypertensive gastropathy （PHG）, esophageal varices and fundal varices was performed. RESULTS： At the end of 12 mo after ligation, hemorrhagic rate was significantly lower in propranolol group than in the control group （38.70% vs 54.54%, P 〈 0.05）. PHG incidence, the incidence of gastric vein, the recurrence rate of venous reflux were significantly lower in propranolol group than in control group （32.25% vs 57.57%, 25.80% vs 42.42%, 29.03% vs 39.39%, all P 〈 0.05）. CONCLUSION： Propranolol reduces rebleeding after endoscopic esophageal variceal ligation, possibly through reducing the occurrences of PHG, esophageal varices and fundal varices.

关 键 词：心得安 食管静脉曲张套扎 再出血 

分 类 号：R575.2[医药卫生—消化系统]