复发性口疮患者肿瘤坏死因子活性水平及病因学意义探讨  

Production of tumor necrosis factor by peripheral blood leukcytes in patients with recurrent oral aphthous ulcer

作　　者：姜军松[1,2] 唐晓农[1,2] 杨志刚[1,2] 马景虎[1,2] 范学东[1,2] 

机构地区：[1]浙江湖州市解放军98医院 [2]北京军事医学科学院

出　　处：《实用口腔医学杂志》1998年第2期117-119,共3页Journal of Practical Stomatology

摘　　要：目的：探讨肿瘤坏死因子（ＴＮＦ）与复发性口疮的关系。方法：采用结晶紫染色法，以Ｌ９２９细胞作为靶细胞，对复发性口疮（ＲＡＵ）活动期与缓解期患者及口腔粘膜外伤患者的外周血单个核细胞分泌ＴＮＦ的水平进行生物活性检测，每例ＲＡＵ配对一位相匹配的健康对照。结果：ＲＡＵ活动期患者未经内毒素诱生的单核细胞、淋巴细胞分泌ＴＮＦ的水平显著升高，而口腔粘膜外伤患者的ＴＮＦ分泌水平与健康对照比较无统计学差异。结论：ＴＮＦ在ＲＡＵ致病机理方面占有重要地位。Objective:To investigate the correlation of tumor necrosis factor with the pathogensis of recurrent aphthous ulceration(RAU). Methods:The production of tumor necrosis factor α(TNF) by peripheral blood leukocytes from aphthous ulcer patitents in active and remission phases of the diseases and from the patitents with non aphthous injury was measured with crystal violet stainning.Each ulcer patitent was matched with a healthy volunteer control. Results:Significantly greater amount of TNF was released from the unstimulated monocyte enriched and monocyte depleted leukocytes fractions in active RAU patients than that from healthy controls( P <0.05).Conclusion:TNF may play an important role in the pathogensis of RAU.

关 键 词：口疮 口腔粘膜溃疡 肿瘤坏死因子 病因学 

分 类 号：R781.502[医药卫生—口腔医学]