抑郁症脑灰质结构和神经认知性别差异  

Gender difference for the gray matter and cognitive dysfunction in depression

作　　者：刘海燕[1] 姚志剑[1] 卢青[2] 王丽[1] 肖朝勇[3] 李宗鸿[3] 滕皋军[4] 

机构地区：[1]南京医科大学,210029 [2]东南大学学习科学研究中心 [3]南京医科大学放射科,210029 [4]东南大学中大医院放射科

出　　处：《临床精神医学杂志》2009年第1期4-6,共3页Journal of Clinical Psychiatry

基　　金：国家自然科学基金项目(30500179);江苏省科学基金项目(BK2005427);南京市医学重点科技发展项目(IKX05003)

摘　　要：目的:探讨抑郁症脑灰质体积和认知功能的性别差异。方法:38例抑郁症患者(男19例,女19例)及29名健康对照(男13名,女16名)均经常规及结构磁共振(MRI)扫描,同时联合反映脑区执行及记忆功能的神经心理学测量,t检验对性别组间数据进行统计分析。结果:①健康男性在右额上回皮质灰质体积较健康女性减小;女性抑郁症患者在右颞叶梭状回及右海马回皮质的灰质体积较男性患者减小(P<0.005,像素>10);②在字色干扰总时间上,健康男性成绩差于健康女性;而抑郁症女性瞬时记忆(数字倒背)项目分数低于男性(P<0.05);③字色干扰总时间的性别差异与右额上回皮质体积性别差异在健康受试中存在相关性(r=0.503,F=4.412,P=0.022);数字倒背的性别差异与右颞叶梭状回及右海马回皮质性别差异在抑郁症患者中未发现显著统计意义的相关(r=0.567,F=2.028,P=0.084)。结论:健康者及抑郁症患者在灰质体积及神经认知上均存在一定的性别差异。Objective： To investigate the gender difference of the gray mater and cognition in patients with depressive disorders Method： 38 depressed patients （male 19, female 19 ） and 29 healthy controls （male 13, female 16） were underwent conventional and stnlcture magnetic resonance imaging,and by a set of standardized neuropsychological test to estimate executive and memory function. Two-sample t-test and muhiple linear regression methods were conducted to compare gender difference between two groups. Results： Male heahhy group showed reduced gray matter volume （GMV） only in the right superior frontal gyms （BA11 ） ;Reduced GMV was found in the right fusiform gyrus of right temporal lobe （BA20） and the right parahippocampal gyrus of limbic lobe （BA36） in female depression than in male （P 〈 0. 005,cluster 〉 10）. For the healthy persons, the stroop test total time were better in female;and for the patients,the male patients were better than female patients in inverse memory of Wechsler memory scale. Correlation were found between stroop test total time and reduced GMV in the right superior frontal gyms gender difference in healtily group （r = 0. 503, F = 4. 412, P =0. 022） ;There is no significant correlation among inverse memory gender difference and the right fusiform gyms of right temporal lobe and the right parahippoeampal gyms of limhic lobe in patient group （ r = 0. 567, F =2. 028,P =0. 084）. Conclusion：Both the heahhy and patients with major depressive disorders have gender difierence for gray matter concentration and neuropsychology cognition.

关 键 词：抑郁症 灰质 神经认知 基于像素的形态学测量 性别差异 

分 类 号：R749.4[医药卫生—神经病学与精神病学]