氟西汀对帕金森病患者抑郁症状和P300的影响  

The effect of fluoxetine on depressive symptoms and event-related potentials P300 in patients with Parkinson's disease

作　　者：李曦[1] 邢红霞[2] 

机构地区：[1]河南科技大学第一附属医院,洛阳471003 [2]新乡医学院第一附属医院

出　　处：《临床精神医学杂志》2009年第1期42-43,共2页Journal of Clinical Psychiatry

摘　　要：目的:观察氟西汀对伴抑郁症状帕金森病患者的治疗效果。方法:49例伴抑郁症状帕金森病患者随机分为氟西汀组和对照组,比较两组治疗前和治疗2周及8周时汉密尔顿抑郁量表(HAMD)得分及事件相关电位P300测定结果。结果:治疗2周及8周后氟西汀组HAMD评分比对照组显著减少(P<0.05或P<0.01),P300中N2、P3潜伏期比对照组显著缩短(P<0.05或P<0.01),P3波幅比对照组显著升高(P<0.05)。结论:氟西汀可改善帕金森病患者的抑郁症状和认知功能。Objective： To explore the treatment effect of fluoxetine hydrochloride on patients with Parkinson＇ s disease with depressive symptoms. Method：49 patients with Parkinson＇ s disease with depressive symptoms were randomly divided into fluoxetine group and control group. HAMD and P300 potential were evaluated before and after two and eight week treatment for the two groups. Results： After two and eight weeks the fluoxetine group showed more significant decrease in HAMD and latencies of N2 and P3 and more significant increase in amplitude of P300 potentials than control group （ P 〈 0. 05 or P 〈 0.01 ）. Conclusion ： Fluoxetine hydrochloride can improve the depressive symptoms and cognition of patients with Parkinson＇ s disease.

关 键 词：氟西汀 帕金森病 抑郁症状 P300 

分 类 号：R749.1[医药卫生—神经病学与精神病学]