122例胃癌患者预后影响因素分析  

Analysis of factors associated with prognosis of 122 gastric cancer cases after operation

作　　者：林婷[1] 丁彦青[1] 李建明[1] 

机构地区：[1]南方医科大学南方医院病理科,南方医科大学基础医学院病理学系,广东省分子肿瘤病理重点实验室,教育部广东省共建人类重大疾病转录组学和蛋白组学重点实验室,广东广州510515

出　　处：《中国热带医学》2009年第3期496-498,共3页China Tropical Medicine

基　　金：国家自然科学基金资助课题(批准号:30500241;30670968和30700286)

摘　　要：目的本研究旨在探讨胃癌患者临床病理特征及其与预后的关系。方法对2005年3月～2008年3月在南方医科大学南方医院普通外科进行胃癌切除手术患者进行随访并进行回顾性分析。采用Kaplan-Meier生存率分析和Cox比例风险模型进行单因素和多因素分析。结果单因素分析显示TNM分期,组织学分型、肿瘤浸润深度、淋巴结转移与术后患者的生存率显著相关(P<0.05);性别、年龄、肿瘤部位及肿瘤分化程度不是影响患者预后的相关因素(P>0.05);Cox分析显示TNM分期是影响胃癌预后的独立因素(P<0.05)。结论TNM分期是影响胃癌患者预后的最重要因素;肿瘤类型、肿瘤浸润深度及淋巴结转移是判断胃癌预后的重要指标。Objective To analyze the prognosis March of gastric cancer patients. Methods There 250 gastric cancer cases who had underwent operation in our hospital from March 2005 to March 2008 were retrospectively analyzed. Kaplan- Meier analysis was used for the univariate analysis, and Cox regression analysis was used for multivariable analysis. Results The univariate analysis showed that TNM classification, tumor type, invasion depth, lymph node metastasis significantly correlated with survival rates （P〈0.05）. sex, age, tumor location, differentiation rarely correlated with prognosis gastric cancer （P〉0.05）. Multivariable analysis showed that TNM classification was an independent prognostic factor of gastric cancer （P〈 0.05）. Conclusion TNM classification is the most important prognostic factor affecting gastric cancer. Tumor type, invasion depth and lymph node metastasis are also the useful prognostic factors for gastric cancer.

关 键 词：胃癌 预后 Kaplan—Meier COX多因素分析 

分 类 号：R735.2[医药卫生—肿瘤]