抑癌基因P16及P53在膀胱移行细胞癌中的表达及意义  

Expression and significance of P16 and P53 gene on bladder transitional cell cancer

作　　者：武玉东[1] 吴海[1] 杨树立[2] 马腾骧[1] 

机构地区：[1]天津市泌尿外科研究所,300211 [2]河南省平顶山市第一人民医院泌尿外科

出　　处：《临床泌尿外科杂志》1998年第1期32-34,共3页Journal of Clinical Urology

基　　金：天津市卫生局科研基金

摘　　要：应用免疫组织化学方法对59例膀胱移行细胞癌中抑癌基因P16及P53的表达进行研究，结果显示：59例膀胱移行细胞癌中P16及P53基因的阳性表达率分别为47.46％和54．24％。P16及P53基因在膀胱移行细胞癌中的阳性表达率在肿瘤病理分级及临床分期等方面分别具有显著性差异（P＜0．05），且P16及P53基因表达之间具有显著相关性（P＜0．05）。提示P16及P53基因的异常表达在膀胱肿瘤的发展过程中起重要作用;P53基因可能对P16基因的表达起调节作用。Immunohistochemical method was used to determine the expression of P16 and P53 gene on 59 cases of bladder transitional cell cancers. The results showed the positive expression rate of P16 and P53 gene was 47. 46% and 54. 24% respectively. Significant differences ekisted inthe expression of both tumor suppressor genes between carcinomas from different pothologicalgrades and clinical stages (P <0.05). There was a significant correlaton between P16 and P53gene expression. I was suggested that the abnormal expressions of P16 and P53 gene might play animportant role in the genesis and the malignant progression of bladder transitional cell cancers－ Expression of P16 gene may be regulated by P53 gene.

关 键 词：膀胱肿瘤 P16基因 P53基因 免疫组织化学 

分 类 号：R737.140.2[医药卫生—肿瘤]