survivin与p53蛋白在结肠癌中的表达及相关性  

Relationship and expression of survivin and p53 in colorectal carcinoma

作　　者：张腾腾[1] 

机构地区：[1]商丘市第一人民医院肿瘤科,河南省商丘476100

出　　处：《中国基层医药》2008年第12期1974-1975,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的研究survivin与突变型p53基因在大肠癌组织中的表达和相关性并探讨其意义。方法采用免疫组织化学sP法检测58例大肠癌组织、25例癌旁组织和39例正常黏膜组织中survivin和p53的表达。结果大肠癌组织中survivin与p53表达阳性率分别为72．4％（42／58）和63．8％（37／58）。大肠癌组织中survivin与p53的阳性表达率高于癌旁组织及正常黏膜组织（P〈0．05）。survivin与p53基因的表达与肿瘤的淋巴转移相关（P〈0．05）。在大肠癌组织中survivin与p53基因的表达显著相关（r=0．291，P=0．020）。结论survivin的过度表达和p53的突变可能在大肠癌的发生和发展中起重要作用。Objective To investgate the expression of survivin and p53 and to evaluate their relationship in coloreetal carcinoma. Methods The expression of survivin and p53 were evaluted using immunohistochemistry in 58 cases of eoloreetal eareinoma tissue ,25 cases of paracarcinoma tissue and 39 cases of normal colonia membranee tissue. Results The positive rates of survivin and p53 in colorectal carcinoma were 72.4% （42/58） and 63.8% （37/ 58）. The positive rates of survivin and p53 in eolorectal carcinoma were significantly higher than paraearcinoma tissue and normal eolonia membrance tissue（ P 〈 0. 05 ）. Survivin and p53 expression were related to metastasis of eoloreetal carcinoma（ P 〈 0. 05 ）. The expression of survivin was obviously correlated with p53 in coloreetal carcinoma （ r = 0. 291 ,P = 0. 020）. Conclusion Overexpression of survivin may play a crucial role in the origin and development of eoloreetal carcinoma.

关 键 词：结肠肿瘤 凋亡抑制蛋白质类 肿瘤抑制蛋白质P53 

分 类 号：R735[医药卫生—肿瘤]