兔肝肿瘤动脉化疗中戊脉安和淀粉微球的调变作用  

Hemodynamic and pharmacokinetic effects of verapamil and microspheres on intraarterial chemotherapy on rabbit hepatic tumor model

作　　者：张苏展[1] 王林波[1] 郑树[1] 

机构地区：[1]浙江医科大学肿瘤研究所,杭州310009

出　　处：《中华实验外科杂志》1998年第1期25-26,共2页Chinese Journal of Experimental Surgery

摘　　要：目的研究戊脉安和淀粉微球肝动脉灌注对化疗药物浓度的调变。方法以新西兰白兔肝VX-2肿瘤动脉化疗为对象测定阿霉素分布改变。结果 2mg/kg戊脉安引起血压下降和心率缓慢,肿瘤和心脏的阿霉素浓度提高。10mg/kg淀粉微球对心血管无影响,在提高肿瘤内阿霉素浓度的同时可降低肝组织和心脏的阿霉素浓度,使阿霉素的瘤肝比例自0.4上升为1.01(P<0.05)。戊脉安和可降解淀粉微球协同作用不明显。结论肝动脉化疗时加用淀粉微球可以减轻化疗的局部和全身毒性,提高治疗指数。Objective To investigate the effects of intraarterial verapamil (VER) and degradable starch micro- spheres (DSM) on hemodynamics and pharmacokinetics of intraarterial adrimycin (ADM). Methods The level of ADM in blood, tumor tissue, liver and heart was measured on the hepatic tumor models of New Zealand rabbits. Results Hepatic arterial infusion of 2 mg/kg VER could cause seriours hypotension and bradycardia with slight increase of tumor ADM level and significant decrease of liver and myocardium ADM levels without hemodynatnic side effects. DSM increased tumor/liver ratio of ADM from 0.4 to 1. 01 (P<0.01). No synergetic effect on tissue ADM level was found in combination of VER and DSM. Conclusion Tissue ADM level could be shifted to tumor by the change in regional blood flow caused by DSM and there was potential benefit to hepatic tumor treatment.

关 键 词：戊脉安 淀粉微球 肝肿瘤 药物疗法 动脉灌注 

分 类 号：R735.705[医药卫生—肿瘤]