Synergistic actions of complement and lysozyme in clearance of Escherichia coli from amphioxus Branchiostoma belcheri  

作　　者：Guangfeng Wang Shicui Zhang Zhimeng Zhuang Zhiping Wang 

机构地区：[1]Department of Marine Biology, Ocean University of China, Qingdao 266003, China [2]Yellow Sea Fisheries Research Institute, Qingdao 266071, China

出　　处：《Progress in Natural Science:Materials International》2009年第2期179-185,共7页自然科学进展·国际材料（英文版）

基　　金：supported by the National Natural Science Foundation of China (Grant No.30730072)

摘　　要：Amphioxus appears to lack free circulating blood cells. How it clears invading pathogens from its body remains unknown to date. We demonstrate here that amphioxus Branchiostoma belcheri is capable of efficiently eliminating the invading bacterium Escherichia coli from its humoral fluid, and the complement and lysozyme are both involved in the elimination of the invading pathogen. Both the com- plement and lysozyme act in concert against the invading bacterium, but the complement appears to play a more dominant role than the lysozyme. 2008 National Natural Science Foundation of China and Chinese Academy of Sciences. Published by Elsevier Limited and Science in China Press. All rights reserved.Amphioxus appears to lack free circulating blood cells. How it clears invading pathogens from its body remains unknown to date. We demonstrate here that amphioxus Branchiostoma belcheri is capable of efficiently eliminating the invading bacterium Escherichia coli from its humoral fluid,and the complement and lysozyme are both involved in the elimination of the invading pathogen. Both the com-plement and lysozyme act in concert against the invading bacterium,but the complement appears to play a more dominant role than the lysozyme.

关 键 词：AMPHIOXUS BRANCHIOSTOMA COMPLEMENT LYSOZYME Humoral fluids Anti-bacterial activity 

分 类 号：R378.21[医药卫生—病原生物学]