酪氨酸磷酸酶SHP-2在膀胱移行细胞癌中表达的初步研究  

A Primary Study of Expressions of Src Homology 2 Domain-Containing Phosphatase SHP-2 in Bladder Transitional Cell Carcinoma

作　　者：战雪梅[1] 董红岩[1] 孙崇伟[1] 

机构地区：[1]临沂市人民医院病理科,山东临沂276003

出　　处：《肿瘤基础与临床》2009年第1期30-32,共3页journal of basic and clinical oncology

摘　　要：目的研究蛋白酪氨酸磷酸酶SHP-2(Src homology 2 domain-containing phosphatase)在膀胱移行细胞癌(bladder transitional cell carcinoma,BTCC)中的表达水平,初步探讨SHP-2与BTCC发生发展的关系。方法收集我院Ⅰ～Ⅲ级BTCC病例,免疫组化染色检测SHP-2表达,显微镜下观察阳性率。取BTCC病例的正常膀胱组织作为对照组。结果各级别BTCC表达SHP-2的阳性率分别为90.9%、100%和90.0%,与对照组(66.7%)相比,各级别BTCC表达SHP-2阳性率显著增高;而各级别BTCC之间SHP-2阳性率无明显差别。结论SHP-2在BTCC组织中的表达显著增高,可能与BTCC发生发展的机制有关;SHP-2在不同级别BTCC组织中的表达无明显差异,提示SHP-2对BTCC的分化程度可能不起重要作用。Objective To study the expressions of Src homology 2 domain-containing phosphatase SHP-2 in bladder transitional cell carcinoma（BTCC） and the relationship between SHP-2 and the development of BTCC. Methods The expressions of SHP-2 were detected by immunohistochemistry in normal bladder tissues and different grades of BTCC. Results The positive rates of SHP-2 products in grade Ⅰ , grade Ⅱ and grade m BTCC were 90.9% ,100% and 90.0% respectively. The expressions of SHP-2 increased significantly in BTCC compared with that in the normal bladder tissues（66.7% ）. Nevertheless, the positive rates of the SHP-2 expression didn＇ t reveal evident change among different grades of BTCC. Conclusion The expressions of SHP-2 increased dramatically in BTCC, which is probably related with the mechanism of the development of BTCC ; the SHP-2 expressions didn＇ t show obvious variation in different grades of BTCC, which suggests SHP-2 perhaps doesn＇ t play an important role in the differentiation degree of BTCC.

关 键 词：蛋白酪氨酸磷酸酶 膀胱移行细胞癌 免疫组织化学 

分 类 号：R737.14[医药卫生—肿瘤]