周剂量多西紫杉醇联合顺铂治疗晚期食管癌的临床观察  

The Clinical Observation of Weekly Docetaxel Combined with Cisplatin in the Treatment of Advanced Esophageal Cancer

作　　者：刘丽萍[1] 郭丽[1] 赵翠云[1] 金娜[1] 王丽霞[1] 李丽清[1] 

机构地区：[1]包头市肿瘤医院肿瘤内科,内蒙古包头014030

出　　处：《肿瘤基础与临床》2009年第1期34-35,共2页journal of basic and clinical oncology

摘　　要：目的观察分析周剂量多西紫杉醇(DTX)联合顺铂(DDP)方案治疗晚期食管癌的近期疗效和毒副反应。方法29例Ⅲ、Ⅳ晚期食管癌,给予周剂量DTX+DDP,即DTX30mg/m2,d1.8.15,DDP40mg,d1～3,21d为1周期,2个周期后按WHO标准评价疗效和毒副反应。结果全组29例,均可评价疗效,总有效率55.2%,初治组(16例)有效率为62.5%,复治组(13例)有效率为46.2%。毒副反应主要表现为白细胞减少、胃肠道反应和脱发。结论周剂量多西紫杉醇联合顺铂治疗晚期食管癌的近期疗效较高,毒副反应轻,值得进一步观察应用。Objective To observe the efficacy and the side effects of weekly docetaxel（DTX） combined with cisplatin（DDP） for treating advanced esophageal cancer. Methods Twenty-nine patients were given DTX 30 mg/m^2 intravenous infusion on d1.8.15, and DDP 40 mg intravenous infusion on d1-3, cycles repeated for 21 days. After two consecutive treatment courses, the evaluation of the short-term efficacy and toxicities were carried out. Results The overall response rate was 55.2% , the response rate of 16 patients in primary treatment was 62.5% and those of relapse treatment were 46.2%. The worst toxicites were bone marrow depression, nausea and vomiting, and alopecia. Conclusion Weekly docetaxel combined with cisplatin as alternative chemotherapy can be used to treat advanced esophageal cancer with less toxicites.

关 键 词：多西紫杉醇 顺铂 食管肿瘤 化疗 

分 类 号：R730.53[医药卫生—肿瘤] R735.1[医药卫生—临床医学]