中成药治疗抗精神病药物引起女性精神分裂症患者闭经的研究  

Effect of traditional medicine on amenorrhea caused by antipsychotics in female patients with schizophrenia

作　　者：解克平[1] 韩莹 

机构地区：[1]山东省淄博市第五人民医院精神科,255120 [2]山东侨联医院心理科

出　　处：《精神医学杂志》2009年第1期25-26,共2页Journal of Psychiatry

摘　　要：目的评估因服用抗精神病药物治疗女性精神分裂症患者引起闭经的中成药治疗的效果和安全性。方法对75例经抗精神病药(奋乃静、舒必利、利培酮)治疗出现闭经的女性精神分裂症患者随机分为中成药治疗组,用益母草膏、大黄虫丸、乌鸡白凤丸辩证施治(共45例)及对照组(共30例)用己烯雌酚加黄体酮系统治疗,一般疗程不超过90天,按自定的疗效标准由医生及患者共同评定疗效(痊愈、显著好转、无效)。结果1、中成药组总的疗效:痊愈27例(60%)、显著好转15例(33.33%)、无效3例(6.67%),显效率93.33%。对照组:痊愈12例(40%),显著好转8例(26.67%)、无效10例(33.33%),显效率66.67%。二组显效率比较差异显著(t=2.73,P<0.05)。2、不良反应:中成药组不良反应轻微,以轻度消化道症状为主,有1例鼻出血,总的不良反应发生率15.55%。对照组不良反应亦以轻度消化系统症状为主,仅1例有经量过多,总的发生率为16.16%。二组相比较无明显差异(t=0.126,P>0.05)。结论用中成药治疗抗精神病物所致女性精神分裂症患者经闭疗效优于西药且较安全。Objective To assess the efficacy and side effects of traditional medicine in the treatment of antipsychotic-induced amenorrhea in female schizophrenic patients. Methods Seventy-five female schizophrenic patients with antipsychotic--induced amenorrhea were randomly assigned to traditional medicine group（45 cases） treated with extract um leonurus sibiricus liquidum, Dahuang zechong pill and Wuji Baifeng pill, or control group （30 cases）with diaethylstilbestrol and progestin. Results The efficacy rate of traditional medicine group was 93. 330/00, that of control group was 66. 670/60, the difference was significant between two groups （t=2.73,P〈 0.05）. The occurring rate of side effects in traditional medicine group was 15.55%, that in control group was 16.16%, no significant difference was found between two groups （t=0. 126 ,P〉0. 05）. Conclusion Traditional medicine has better efficacy and fewer side effects for treating amenorrhea caused by antipsychotics in female patients with schizophrenia.

关 键 词：精神分裂症 女性 闭经 中成药 

分 类 号：R749.3[医药卫生—神经病学与精神病学]