天普洛安对食管癌手术患者肺组织的保护作用  

Protective effect of ulinastatin on lung tissues of esophageal carcinoma patients who underwent esophagectomy

作　　者：王功朝[1] 王春芹[2] 潘爱春[1] 王洲[2] 

机构地区：[1]山东大学护理学院外科教研室,山东济南250012 [2]山东省立医院胸外科,山东济南250021

出　　处：《中华肿瘤防治杂志》2009年第2期135-137,共3页Chinese Journal of Cancer Prevention and Treatment

摘　　要：目的:探讨天普洛安对食管癌手术患者肺组织的保护作用。方法:80例食管癌患者随机分成两组,各40例,实验组术前3 d及术后7 d应用天普洛安,每天2×105u,用Elisa法检测手术前及手术后0、6、24和72 h血清TNF-α、IL-1β水平,同时检测动脉血氧合指数,记录患者胸腔引流量及胸管拔除时间。结果:术前tTNF-α=1.357,P>0.05,tIL-β=1.41,P>0.05;术后0 htTNF-α=3.616,P<0.01,tIL-β=6.46,P<0.01;术后6 htTNF-α=2.559,P<0.05,tIL-β=12.26,P<0.01;术后24 htTNF-α=3.731,P<0.01,tIL-β=0.23,P>0.05;术后72 htTNF-α=1.943,P>0.05,tIL-β=1.14,P>0.05。天普洛安显著降低食管癌患者术后血清TNF-α、IL-1β水平。实验组食管癌患者术后动脉血氧合指数较对照组显著增加,P均<0.01。结论:天普洛安显著降低实验组食管癌患者术后血清TNF-α、IL-1β水平,对术后肺炎症反应有保护作用。OBJECTIVE： To investigate the protective effect of ulinastatin on inflammatory reaction in patients who underwent esophagectomy. METHODS： Eighty esophageal carcinoma patients were randomly divided into two groups（n-40 each）, a ulinastatin group and control group. The ulinastatin group recevied 2 × 10^5 units of ulinastatin continuosly for 3 days before the operation and 7 days after the operation. Serum TNF-α and IL-1β concentrations were detected at 0,6,24 and 72 h before and after the operation by the ELISA method. Oxygen indexes（OI） in aterial blood gas were detected at 0,6,24 and 72 h before and after the operation in both groups. RESULTS： The serum levels of TNF-α and IL-1β, and OI had no significant difference between the two groups before the operation, tTNF-α = 1. 357, P〉0.05 ,tIL-β= 1. 41 ,P〉0. 05, and had a significant difference between the two groups after the operation, 0 h tTNF-α =3.616,P〈 0.01,tIL/β 6. 46,P〈0. 01; 6 htTNF-α=2.559,P〈0. 05,tIL-β=12.26, P〉0.01;24 hgTNF-α=3.731,P〈0.01, tIL-β 0.23, P〉0.05; 72 hafter operation, tTNF-α=1. 943, P〉0.05, tIL-β=1.14, P〉0.05. Ulinastatin could decrease the TNF-α and IL-1β significantly. OI in ulinastatin group was increased significantly than that in control group （P〈0.01）. CONCLUSION： Ulinastatin can reduce the serum levels of TNF-α and IL-1β significantly and has a certain protective effect on lung inflammatory reaction.

关 键 词：肿瘤坏死因子-Α 白介素-1Β 急性肺损伤 天普洛安 

分 类 号：R735.1[医药卫生—肿瘤]