原发性肝细胞性肝癌中dysadherin的表达及意义  

Expression of dysadherin and its significance in primary hepatocellular carcinomas

作　　者：刘丹丹[1] 陈丽荣[2] 罗利敏[3] 

机构地区：[1]浙江医学高等专科学校病理教研室,杭州310053 [2]浙江大学附属二院病理科,杭州320009 [3]浙江省人民医院放疗科,杭州310014

出　　处：《临床与实验病理学杂志》2008年第6期661-663,667,共4页Chinese Journal of Clinical and Experimental Pathology

基　　金：浙江省教育厅科研项目(20050343)

摘　　要：目的探讨抗黏附素(dysadherin)在原发性肝细胞性肝癌(hepatocellular carcinama,HCC)中表达的临床病理学意义。方法应用免疫组化SP方法,检测90例肝癌组织中dysadherin的表达,分析其与HCC各临床病理学参数之间的关系。结果原发性HCC组织中dysadherin的表达和和患者的HBsAg阳性率、2年生存率、HCC的Edmondson分级、TNM分期、有无肿瘤包膜及肝内转移等因素有显著关系,和E-cad蛋白的表达呈负相关关系。结论dysadherin可能是判断HCC的恶性程度和患者预后信息的重要指征。Purpose To explore the expression and clinicopathologieal significance of dysadherin in primary hepatocellular cacinomas. Methods Immunohistochemical SP method was used to detect the expression of dysadherin in 90 cases of primary hepatocellular carcinomas. And the relationship with all clinicopathological parameters was analyzed. Results Dysadherin expression in primary hepato- cellular carcinoma tissues was closely related with HBsAg expression, two-year survival rate, Edmondson grade, TNM stage, tumor encapsulation and intrahepatic metastasis, and negatively correlated with E-cad expression. Conclusions Dysadherin may be an important prognostic indicator to evaluate the malignant degree and prognostic information of hepatocellular carcinoma patients.

关 键 词：肝肿瘤 肝细胞性肝癌 抗黏附素 

分 类 号：R735.7[医药卫生—肿瘤]