唑来膦酸治疗恶性肿瘤骨转移疼痛疗效观察  

Therapeutic observation of Zoledronic acid in the treatment of pain caused by metastatic bone tumors

作　　者：徐建芳[1] 刘驯炎[1] 杨宏凯[1] 周岚[1] 

机构地区：[1]广东省汕头市中心医院肿瘤内科,515031

出　　处：《临床合理用药杂志》2009年第2期7-8,共2页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的观察唑来膦酸对恶性肿瘤骨转移疼痛的治疗效果和安全性。方法对47例恶性肿瘤骨转移患者用唑来膦酸4mg加入生理盐水100ml静脉滴注,滴注时间30～40min,间隔4周重复给药1次,连续给药2次后评价疗效和不良反应。结果总有效率为80.8%(38/47),其中显效25.5%(12/47),有效55.3%(26/47);不良反应为头晕、乏力、发热及一过性骨痛等,发生率较低。结论唑来膦酸治疗恶性肿瘤骨转移疼痛有良好疗效,不良反应较轻,患者易于耐受,值得临床推广使用。Objective To observe the therapeutic effect and safety of zoledronic acid in the treatment of patients with pain caused by metastatic bone tumors. Methods 47 patients with pain caused by metastatic bone tumors were treated with zoledronic acid 4mg ＋0.9% NS 100ml intravenous infusion in 30 -40 minites, The treatment was repeated at 4 weeks intervals, the effect and toxicity was assessed after continuous twice treatment. Results The overall response rate of zoledronie acid was 80.8% （38/47）. excellent rate was 25.5% （12/47） ,effective was 55.3% （26/47）. The main adverse effects were dizziness,hypodynamia, pyrexia and temporarily ostealgia, their incidence rate is lower. Conclusion Zoledronic acid can relieve the pain of metastatic bone tumors effectively with little adverse effects,It is acceptable and worth to used in clinic.

关 键 词：肿瘤 骨转移 疼痛 唑来膦酸 

分 类 号：R730.5[医药卫生—肿瘤]