血管内皮生长因子过表达对肺癌生成及转归的影响  

Effect of VEGF on the progression and the prognosis in lung cancer

作　　者：穆海玉[1] 沈春燕[1] 陶盟[1] 

机构地区：[1]天津武警医学院附属医院肿瘤中心,天津300162

出　　处：《癌症进展》2009年第1期101-105,共5页Oncology Progress

摘　　要：目的研究血管内皮生长因子(VEGF)在非小细胞肺癌的阳性表达影响肺癌进展和预后的作用机制。方法应用免疫组化SABC染色法检测40例原发性支气管肺癌标本中VEGF的阳性表达、微血管密度(MVD)计数,评价VEGF和MVD的关系、VEGF与非小细胞肺癌临床病理参数之间的关系。结果VEGF在非小细胞肺癌组织中呈现阳性高表达,其含量及阳性表达与肿瘤大小和淋巴结转移密切相关。肿瘤直径越大、已有淋巴结转移,则VEGF含量和表达越高。在VEGF表达阳性的癌组织中MVD值明显高于VEGF阴性表达的肺癌组织,差异具有统计学意义。结论VEGF通过调节和诱导肺癌微血管的生成而促进非小细胞肺癌的发展,它可作为评估非小细胞肺癌恶性程度、淋巴结转移潜能和预后的重要监测指标之一。Objective To explore the positive expression of vascular endothelial growth factor （VEGF） in nonsmall cell hung cancer. Methods VEGF positive expression were detected by immuno histochemistry and image analysis technique. Results The VEGF positive expression was mainly located in the cytoplasm of lung cancer. The positive rate of VEGF in non-small cell lung cancer was significantly higher than that in non-lung cancer. The VEGF positive expression level increased along with the increase of tumor size and metastasis level. Microvascular density was notably higher in the tissue specimens of VEGF positive expression. Conclusion VEGF play an important role in the growth and metastasis of non-small cell lung cancer.

关 键 词：非小细胞肺癌血管内皮生长因子微血管密度血管生成 

分 类 号：R734.2[医药卫生—肿瘤] R730.7[医药卫生—临床医学]