紫杉醇导致过敏的防治  

Control of the hypersensitivity reaction of taxane family

作　　者：王正艳[1] 李向东[1] 

机构地区：[1]锦州市中心医院肿瘤科,锦州121000

出　　处：《癌症进展》2009年第1期114-116,共3页Oncology Progress

摘　　要：目的探索简便可靠的紫杉类药物激素预处理方法及重度过敏反应后再输注的可能性。方法在注药前12h、6h各口服地塞米松10mg,紫杉醇输注前半小时口服苯海拉明50mg,静点西米替丁400mg,肌注异丙嗪25mg。结果共发生与紫杉醇输注相关性过敏反应50例,其中36例发生荨麻疹,12例出现面色潮红、胸闷、气急,1例出现头晕、视物模糊、心悸,1例出现过敏性休克。过敏反应发生率为10.3%。结论本组测验结果与国内外报道的过敏发生率明显减低,说明该激素预处理方法及发生过敏反应时的治疗流程有效,安全可靠。Objective To investigate a simple method to manage severe hypersensitivity reaction for continuing administration taxane family. Methods Dexamethasoni 10mg were given orally 12 hours and 6 hours before infusion of taxane, and 30 minutes before injection of taxane dimenhydrinate 50mg, cemitidi 400mg, promethazine 25mg was given. Results Totally 50 cases of hypersensitivity reactions were recorded, including urticaria （n = 36）, flush, chest distress and short breath （n = 12 ）, dizziness and ocular blurring/palpitation （ n = 1 ）, anaphylactic shock （ n = 1 ）. Hypersensitivity reaction rate was 10. 3%. Conclusion The incidence of hypersensitivity reaction of taxane family is lower in our experimental result compared with worldwide, demonstrating that steroid premedication is safe and effective.

关 键 词：紫杉醇 过敏反应 

分 类 号：R730.53[医药卫生—肿瘤]