环孢菌素A高产菌株摇瓶发酵及菌丝体的形态变化  

The optimum of fermentation process and observation of the filamentous morphology of Beauveria nivea CA411 producing cyclosporin A

作　　者：郑孝贤[1] 邱观荣[1] 唐信东[1] 程元荣[1] 

机构地区：[1]福建省微生物研究所福建省新药(微生物)筛选重点实验室,福州350007

出　　处：《中国抗生素杂志》2009年第2期97-99,共3页Chinese Journal of Antibiotics

摘　　要：研究雪白白僵菌CA411产环孢菌素A的摇瓶发酵条件,使该菌株的发酵效价提高了110%以上。采用补水发酵工艺,提高菌体生长速度,使发酵周期缩短2d。对摇瓶发酵过程中的细胞形态进行观察,初步揭示发酵各时期菌体形态变化。The optimal fermentation process of Beauveria nivea CA411 producing cyclosporin A was studied. The fememtation potency of cyclosporin A was increased by approximately 110% at the optimal growth parameters. The fermentation period could be decreased by 2 days. During fermentation, water feeding process was used to increase the culture growth, while the morphological changes of the culture at different growth stages were observed under the optical microscope.

关 键 词：环孢菌素A 雪白白僵菌 发酵工艺 菌丝形态 

分 类 号：R979.1[医药卫生—药品]