E_(26)转录因子-1(Ets-1)与妇科恶性肿瘤的研究进展  

Research Progress in E_(26) Transformation Specific-1 (Ets-1) in Gynecologic Malignancies

作　　者：张蕾[1] 杨永秀[1] 

机构地区：[1]兰州大学第一医院,甘肃兰州730000

出　　处：《中国肿瘤》2009年第2期131-135,共5页China Cancer

摘　　要：E26转录因子-1(Ets-1)基因是一种原癌基因,介导细胞增殖、分化和恶性变,其过度表达和多种人类肿瘤的发生、发展、浸润及转移有密切相关。Ets-1基因在转录水平通过促进基质蛋白水解和血管生成、调节细胞黏附、参与细胞凋亡以及提高肿瘤细胞缺氧耐受等机制参与多种肿瘤的侵袭和转移。近年来的研究表明,在妇科恶性肿瘤中Ets-1表达与肿瘤细胞的分化程度、临床病理分期、组织学类型、浸润和转移、患者的预后相关。抑制Ets-1能有效抑制肿瘤细胞生长、转移和肿瘤血管生成。Ets-1基因已成为妇科肿瘤治疗的新靶点。E26 Transformation Specific-1 （Ets-1） gene is one of the proto-oncogene. It can mediate cell proliferation, differentiation and malignancy. The overexpression of Ets-1 intimately correlates to the carcinogeuesis, infiltration and metastasis in many human tumors. Ets-1 gene participates the invasion and metastasis of many kinds of tumors by some mechanisms such as promoting matrix protein proteolysis, angiogenesis, regulating cell adhesion, participating apoptosis, and elevating tumor cell hypoxia tolerance. Recent studies have shown that the expression of Ets-1 in gynecologic malignancies is correlated to degree of differentiation, clinic pathological staging, histological type, invasion, metastasis and prognosis. The inhibition of Ets-1 is an available way to repress cell growth, metastasis and angiogenesis in cancers. Ets-1 is a new molecular therapeutic target for gynecologic malignancies.

关 键 词：妇科肿瘤 E26转录因子-1 靶向治疗 

分 类 号：R737.3[医药卫生—肿瘤]