早期乳腺癌CEAmRNA阳性循环细胞检测及其临床意义  

Detection of CEA mRNA-positive Circulating Tumor Cells in Patients with Early Breast Cancer and Its Clinical Sig-nificance

作　　者：陈艳[1] 谷玉兰[1] 刘馨[1] 金从国[1] 周永春[1] 王熙才[1] 伍治平[1] 邹天宁[2] 

机构地区：[1]昆明医学院第三附属医院肿瘤研究所,云南昆明650118 [2]云南省肿瘤医院,云南昆明650118

出　　处：《中国肿瘤》2009年第2期155-158,共4页China Cancer

基　　金：云南省教育厅基金(04Y0298C)

摘　　要：[目的]研究早期乳腺癌外周血中CEA mRNA阳性循环肿瘤细胞的临床意义。[方法]检测50例早期乳腺癌患者、24例乳腺良性疾病患者和20例健康志愿者外周血CEA mRNA阳性细胞。[结果]早期乳腺癌患者外周血CEA mRNA阳性率为14.0%,CEA mRNA阳性率与TNM分期(P=0.004)、肿瘤大小(P=0.027)、血清CEA(P=0.000)水平异常升高显著性相关。CEA mRNA阳性患者中位无瘤生存期为18个月,与阴性患者比较差异有统计学意义(P=0.000)。[结论]CEA mRNA阳性循环肿瘤细胞可能是早期乳腺癌患者监测复发转移的重要指标和独立的预后因素。[Purpose ] To investigate the clinical significance of CEA mRNA-positive circulating tumor cells in peripheral blood in patients with early breast cancer. [Methods ] The CEA mRNA-positive circulating tumor cells in peripheral blood of 50 cases with early breast cancer, 24 cases with breast benign lesions and 20 healthy individuals were detected. [Results ] The CEA mRNA positive rate in early breast cancer was 14.0%. Positive CEA mRNA significantly correlated to TNM stage （P= 0.004）, tumor size （P=0.027）, and serum CEA levels（P=0.000）. Median relapse-free time in positive CEA mRNA patients was 18 months, which was lower than that in negative CEA mRNA patients. [Conclusion] CEA mRNA positive cell may be an important predictor for recurrece and metastasis in early breast cancer patients. It is an independent prognostic factor.

关 键 词：乳腺肿瘤 循环肿瘤细胞 微转移 CEA 

分 类 号：R737.9[医药卫生—肿瘤] R73-12[医药卫生—临床医学]