恶性肿瘤微转移检测技术研究  

Detection of Micrometastases in Malignant Tumor

作　　者：罗光明（综述）[1] 杨湛（审校） 

机构地区：[1]昆明市第一人民医院口腔科,昆明650011 [2]云南省第三人民医院口腔外科,昆明650011

出　　处：《医学综述》2009年第4期613-615,共3页Medical Recapitulate

摘　　要：由于微转移的存在，部分癌症患者外科手术后出现复发。常规术前影像研究及手术中的观察不能检查到微转移。近年来，分子生物学技术在外周血、骨髓抽吸物、淋巴结、腹膜冲洗液中检测到微转移；该技术比HE染色、免疫组织化学染色等其他方法更准确而敏感。分子生物学技术检测微转移关键是寻找特异性分子标记。A certain percentage of patients with cancer suffer from recurrences following surgery with curative intent because of the presence of micrometastases. The existence of micrometastases cannot be detected by routine preoperative imaging studies and intraoperative observations. In recent years, such micrometasrases have been detected from various clinical samples such as peripheral blood, bone marrow aspirates, lymph nodes, and peritoneal washes, using molecular biology techniques, and they are more accurate and sensitive than hematoxylin and eosin staining,immunohistnchemical staining and other methods. The key of the molecular biology techniques is to seek specific molecular markers.

关 键 词：肿瘤 微转移 分子标志物 

分 类 号：R730.9[医药卫生—肿瘤]