绿色氯化技术在农药中间体合成中的应用  

Application of Green Chlorination Techniques in the Synthesis of Pesticide Intermediates

作　　者：杜晓华[1] 任旭康[1] 骆大为[1] 葛林丹[1] 许响生[1] 陈瑨[1] 严中杰[1] 徐振元[1] 

机构地区：[1]浙江工业大学催化加氢研究中心,杭州310014

出　　处：《现代农药》2009年第1期24-26,54,共4页MODERN AGROCHEMICALS

基　　金：浙江省绿色化工重大科技专项(2008C01061–2)

摘　　要：盐酸-双氧水可替代液氯进行芳胺的亲电氯化,在农药中间体2,6-二氯-4-三氟甲基苯胺和4-氯-2-三氟甲基苯胺的合成上十分有效。双(三氯甲基)碳酸酯替代氯化亚砜、硫酰氯、三氯氧磷、五氯化磷、三氯化磷、光气等氯化剂,用于菊酰氯、苯甲酰氯、苯磺酰氯、氯代亚胺等农药中间体的合成。两种氯化方法的E因子显著小于传统方法。HC1-H2O2 was used in the electrophilic chlorination of aromatic amines to replace liquid chlorine. Good results were obtained in the synthesis of 2,6-dichloro-4-trifluoromethylaniline and 4-chloro-2-trifluoromethylaniline. Bis（trichloromethyl）carbonate was applied in the synthesis of chrysanthemyl chloride, benzoyl chloride, benzesulfonyl chloride and imide chloride to replace such chlorination agents as thionyl chloride, sulfonyl chloride, phosphorusoxychloride, phosphorus pentchloride, phosphorus trichloride and phosgene. The two chlorination methods both give lower E factors.

关 键 词：氯化 盐酸-双氧水 双(三氯甲基)碳酸酯 E因子 

分 类 号：TQ450.4[化学工程—农药化工]