CT灌注成像对胶质瘤术后监测的临床意义  

Clinical significance of CT perfusion image on post- operative follow- up of glioma

作　　者：杨奉常[1] 宋爱芹[2] 郁海英[1] 李文武[1] 申洪明[1] 

机构地区：[1]山东省肿瘤防治研究院放射科,济南250117 [2]即墨市中医院放射科

出　　处：《国际肿瘤学杂志》2009年第2期155-158,共4页Journal of International Oncology

摘　　要：目的探讨多层螺旋CT灌注成像在胶质瘤术后随访中的临床意义。方法对32例胶质瘤术后患者行CT灌注成像，测量术后复发残留病变、术后未复发残留病变及脑组织正常区域的CT灌注参数值，包括脑血容量（CBV）、脑血管表面通透性（PS），以及其各相对参数值（rCBV、rPS）。应用SPSS12．0统计软件包，独立样本t检验进行统计学分析。结果复发残留组16例中，CBV值12例升高，4例接近正常值，Ps值均升高。rCBV值〉2．6者10例中，最大rCBV值为4．01，平均rCBV值为2．67，平均rPS值为6．32。未复发残留组16例中，CBV值7例接近正常值，2例升高，7例降低；PS值11例接近正常，3例降低，2例升高；rCBV值均〈2．6，最大值为2．14，平均rCBV值为0．99，平均rPS值为1．42。复发残留组分别与未复发残留组和脑组织正常区域比较，CT灌注参数值差异均有统计学意义（P〈0．01）；未复发残留组与脑组织正常区域比较，CT灌注参数值差异均未有统计学意义（P〉0．05）；复发残留组与未复发残留组rCBV差异及rPS差异均具有统计学意义（P〈0．01）。结论CT灌注成像在确定胶质瘤术后是复发、残留还是未复发或残留上有重要价值。Objective To assess the clinical value of multi-slice helical CT perfusion on the post-op- erative follow-up of glioma. Methods CT perfusion image was applied to 32 patients with glioma after opera- tion. Various perfusion parameters, include cerebral blood volume（ CBV）, permeability surface（ PS）, relative cerebral blood volume （rCBV） and relative permeability surface （rPS） were measured on recurrent area, non- recurrent area and normal cerebral area respectively. SPSS 12. 0 statistical software was used. Independent t test was used to compare the differences. Results In the recurrent group （16 cases）, the value of CBV in- creased in 12 cases and was normal in the other 4 cases. The value of PS increased in all the cases of recurrent group. The value of rCBV exceeded 2.6 in 10 cases, among which the biggest value of rCBV was 4. 01. The mean value of rCBV was 2. 67 and the mean value ofrPS was 6. 32; In the non-recurrent group（ 16 cases）, the value of CBV was nearly normal in 7 cases, increased in 2 cases and decreased in the remaining 7 cases. The value of PS was nearly normal in 11 case, decreased in 3 cases and increased in the remaining 2 cases. The values of rCBV were all less than 2. 6 and the biggest value of rCBV was 2. 14. The mean value of rCBV was O. 99 and the mean value of rPS was 1.42. The statistic significance was obtained for all the parameters when compared the recurrent group with the non-recurrent group（ P 〈0. 01 ）and with the normal cerebral area（ P 〈 0. 01 ）. When compared the non-recurrent group with the normal cerebral area, none of the parameters had sta- tistic significance （ P 〉 O. 05 ） ; The statistic significance was obtained for rCBV and rPS when compared the recurrent group with the non-recurrent group （ P 〈 O. 01 ）. Conclusion CT perfusion image is valuable in determining glioma recurrence after operation.

关 键 词：神经胶质瘤 灌注 局部 体层摄影术 X线计算机 随访研究 

分 类 号：R730[医药卫生—肿瘤] R73[医药卫生—临床医学]