肝癌中Bcl-2、Bax和C-myc基因的表达及其临床意义  

Expression and clinical significance of Bcl-2,Bax and C-myc in hepatocellular carcinoma

作　　者：杨闯[1] 魏振彤[2] 郑宇[3] 王广义[1] 

机构地区：[1]吉林大学第一医院普外科,吉林长春130021 [2]吉林大学第一医院妇产科 [3]哈尔滨市第一医院普外科

出　　处：《中国老年学杂志》2009年第4期450-451,共2页Chinese Journal of Gerontology

基　　金：吉林省科技厅基金资助课题(200507083);吉林省政府基金资助课题(20071500)

摘　　要：目的探讨Bcl-2、Bax和C-myc基因表达在肝细胞癌(HCC)中的临床意义。方法采用免疫组化技术检测不同HCC组织、癌旁组织及正常肝组织中的Bcl-2、Bax和C-myc蛋白表达。结果Bcl-2、Bax和C-myc在HCC组织、癌旁组织和正常肝组织中均有部分阳性表达;Bcl-2和C-myc蛋白在HCC组织中呈高表达,其个体阳性率明显高于正常肝组织(P<0.05);Bax蛋白在HCC组织中呈低表达,其个体阳性率明显低于正常肝组织(P<0.05);Bcl-2基因的表达与HCC的发病年龄、性别、肿瘤大小、UICC分期和转移均无关;Bax基因的表达与HCC的发病年龄、性别、肿瘤大小和转移无关(P>0.05),而与HCC的UICC分期有关(P<0.05);C-myc基因的表达与HCC的发病年龄、性别、肿瘤大小和UICC分期无关(P>0.05),而与HCC的转移有关(P<0.05)。结论Bcl-2、Bax和C-myc基因相互协调作用,促进HCC的发生和发展。Objective To investigate the expressions＇and the clinical significance of Bcl-2, Bax and C-myc gene in hepatocellular carcinoma（HCC）. Methods Bcl-2, Bax and C-myc gene＇s expressions in HCC tissue, paracancerous tissue and normal liver tissue were detected by immunohistochemistry. Results The rates of Bcl-2 and C-myc positive expressions in HCC tissue were higher than those in normal liver tissue （P 〈 0. 05 ）. The rate of Bax in HCC tissue was lower than that of normal liver tissue （ P 〈 0.05 ）. The expression of Bcl-2 had no association with the patients＇ age, sex, the size of tumor, UICC stage and the metastasis （P 〉 0. 05 ）. The expression of Bax had no association with the patients＇ age, sex, the size of tumor and the metastasis （P 〉 0. 05 ）, but had some association with UICC stage of HCC （ P 〈 0. 05 ）. The expression of C-myc had no association with the patients＇ age, sex, the size of tumor and UICC stage （ P 〉 0. 05 ）, but had some association with the metastasis of HCC （ P 〈 0.05 ）. Conclusions Bcl-2, Bax and C-myc gene maybe cooperate to promote the occurrence and development of HCC.

关 键 词：肝细胞癌 BCL-2 BAX C-MYC 

分 类 号：R735.7[医药卫生—肿瘤]