介入化疗栓塞在宫颈癌术前的临床应用  

The preoperative interventional chemoembolization for the treatment of cervical cancer:its clinical application

作　　者：张国福[1] 田晓梅[1] 韩志刚[1] 王雪珍[1] 王冬燕[1] 徐丛剑 

机构地区：[1]复旦大学附属妇产科医院放射科,上海200011 [2]中西医结合科

出　　处：《介入放射学杂志》2009年第2期97-99,共3页Journal of Interventional Radiology

摘　　要：目的探讨Ⅰb-Ⅱb期宫颈癌术前介入化疗栓塞的临床疗效、病理学改变。方法对2006年1月至2007年12月在我院就诊的75例宫颈癌患者实施术前动脉介入化疗,抗癌药物为顺铂、表阿霉素和博来霉素,灌注化疗后用明胶海绵栓塞肿瘤供血动脉。结果75例宫颈癌患者经1～2次术前介入性化疗后顺利手术切除;术后标本病理切片中可见大量坏死组织及淋巴细胞浸润,其中组织学完全缓解3例。结论宫颈癌术前介入性化疗可有效缩小肿瘤体积、减少术中出血,部分患者达到组织学完全缓解的效果。Objective To assess the effectiveness of preoperative interventional chemoembolization in the treatment of cervical cancer and to observe the pathological changes of the tumor after the procedure. Methods During the period of Jan. 2006 - Dec. 2007, preoperative interventional chemoembolization was performed in 75 patients with cervical cancer. The antineoplastic drugs included cisplatin, epirubicin and BLM. In all patients, interventional arterial infusion chemotherapy was carried out before the embolization of bilateral tumor-feeding arteries with gelfoam was made. Results Seventy-five patients underwent radical resection surgery after receiving 1 or 2 times of chemoembolization. Pathologically, massive necrosis and lymphocytic infiltration were found within the tumor, and histological complete remission （HCR） was seen in 3 patients. Conclusion For the treatment of cervical cancer, the preoperative interventional chemoembolization can effectively decrease the tumor size and reduce blood loss during operation, moreover, even HCR can be obtained in some patients. （J Intervent Radiol, 2009, 18： 97-99）

关 键 词：宫颈癌 介入性化疗 病理评价 

分 类 号：R737.33[医药卫生—肿瘤]