Ki-67、VEGF和p27在急性白血病中的表达及其相关性研究  

Correlation and expression of Ki-67, VEGF and p27 expressed in patients with acute leukemia

作　　者：朱娟[1] 刘延方[2] 孙慧[2] 王秋红 韩利杰[4] 

机构地区：[1]河南省人民医院急诊科,郑州450003 [2]郑州大学第一附属医院血液科 [3]济源市第一人民医院血液肿瘤科 [4]郑州市第三人民医院血液科

出　　处：《白血病．淋巴瘤》2009年第2期96-97,101,共3页Journal of Leukemia & Lymphoma

摘　　要：目的探讨Ki-67、VEGF和p27在急性白血病（AL）中的表达及其相关性。方法采用免疫细胞化学染色测定AL患者骨髓单个核细胞中Ki-67、VEGF和p27的表达。结果AL细胞表达Ki-67（42．48±25．78）％或VEGF（44．89±24．01）％的水平均显著高于对照组（11．40±9．94）％或（16．90±12．54）％（P〈0．01），而p27的表达（23．65±13．30）％明显低于对照组（50．23±22．68）％（P〈0．01）；Ki-67与VEGF及p27的表达分别呈正相关（r=0．666，P〈0．01）和负相关（r=-0．316，P〈0．05）。结论Ki-67、VEGF和p27在AL细胞中的表达对研究AL的发生机制及其诊断有价值。Objective To explore the role and their relationship of Ki-67, VEGF and p27 expressed in adult patients with acute leukemia. Methods The expression of Ki-67, VEGF and p27 in bone marrow mononuclear cells （BMMNC） were analyzed by innnunocytochemical staining, and their correlations of Ki-67, VEGF and p27 were statistically analyzed. Results The expression of Ki-67（42.48±25.78） % or VEGF （44.89±24.01） % on BMMNC from acute leukemia cells was significantly higher than that in the control （11.40±9.94） % or （16.90±12.54） % （P 〈0.01）. But the expression of p27 （23.65±13.30） % was significantly lower than that in the control （50.23±22.68） % （P 〈0.01）. The expressions of Ki-67 were positively correlated with and VEGF in patients with acute leukemia were positively correlated（r =0.666, P 〈0.01）, and the expressions of Ki-67 and p27 were negatively correlated with p27 in patients with acute leukemia （r = -0.316, P 〈0.05）. Conclusion The evaluation of expression of Ki-67, VEGF and p27 on acute leukemic cells provides new insights to the pathogenesis is helpful in mechanism and is helpful in the diagnosis of acute leukemia.

关 键 词：白血病 急性 KI-67抗原 血管内皮生长因子类 周期素依赖激酶抑制剂P27 

分 类 号：R733[医药卫生—肿瘤]