环氧化酶2在胃底贲门癌及远端食管癌中表达的研究  

The Expression of Cyclooxygenase 2 in Adenocarcinomas of Gastric Cardia and Distal Esophagus

作　　者：王铁[1] 田立宁[2] 汪东杰[3] 高梅鹜[3] 吕洪光[3] 

机构地区：[1]哈尔滨医科大学附属肿瘤医院胃肠外科,150081 [2]哈尔滨医科大学附属第一医院耳鼻咽喉及头颈外科,150001 [3]哈尔滨医科大学附属第一医院普外四科,150001

出　　处：《国际遗传学杂志》2009年第1期6-7,13,共3页International Journal of Genetics

基　　金：黑龙江省教育厅基金（11531199）

摘　　要：目的研究COX-2在贲门癌及远端食管癌中的表达。方法应用免疫组化的方法研究手术切除的210例远端食管癌和213例胃底贲门癌标本中COX-2的表达情况。结果远端食管癌组COX-2的表达率及强阳性率均高于胃底贲门癌组（χ^2分别为14．367和63．907，P〈0．05）；胃底贲门癌组，COX-2阳性细胞主要位于肿瘤边缘；远端食管癌组，COX-2阳性细胞主要位于肿瘤中心。结论胃底贲门癌及远端食管癌可能是两种性质及起源不同的肿瘤。Objectives To analyse the expression of cyclooxygenase 2 （COX-2） in carcinomas of cardia and distal esophagus. Methods Tumor sections of 210 patients with adenocarcinoma of distal esophagus and 213 patients with adenocarcinoma of gastric cardia were immunohistochemically stained using a COX-2 monoclonal antibody. Results COX-2 expression in adenocarcinoma of distal esophagus was significantly higher than that of gastric cardia（ χ^2 = 14. 367 and 63. 907 ,P 〈0. 05 ）. The main position of COX-2 expression in gastric cardia was the margin of the tumor, and the center of the tumor was in distal esophagus. Conclusion Adenocarcinomas of the gastric and distal esophagus may be two different tumors.

关 键 词：环氧化酶2 胃底贲门癌 远端食管癌 

分 类 号：R735.2[医药卫生—肿瘤] R735.1[医药卫生—临床医学]